KDM2A

Gene Symbol KDM2A
Entrez Gene 22992
Alt Symbol CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 2A
Other Description CXXC-type zinc finger protein 8|F-box and leucine-rich repeat protein 11|F-box/LRR-repeat protein 11|[Histone-H3]-lysine-36 demethylase 1A|jmjC domain-containing histone demethylation protein 1A|jumonji C domain-containing histone demethylase 1A|lysine-specific demethylase 2A
Swissprots Q69YY8 Q4G0M3 I3VM55 E9PIL6 Q9UK66 D4QA03 Q9BVH5 Q9Y2K7 Q9H7H5 Q49A21
Accessions CCO13754 EAW74578 EAW74579 EAW74580 Q9Y2K7 AB023221 BAA76848 AB490246 BAJ05817 AF179221 AAD56012 AI185920 AK022684 AK024505 BAB15795 AK128293 AK299725 BAG61623 AL117517 CAH10721 BC001203 AAH01203 BC027467 BC047371 AAH47371 BC047486 AAH47486 BC056905 BC064360 AAH64360 BE675843 DR001963 JQ710741 AFK81540 JQ710742 AFK81541 JQ710743 AFK81542 JQ710744 AFK81543 XM_006718479 XP_006718542 XM_006718480 XP_006718543 XM_011544860 XP_011543162 XM_011544861 XP_011543163 XM_011544862 XP_011543164 NM_001256405 NP_001243334 NM_012308 NP_036440 NR_027473
Function Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.
Tissue Specificity Widely expressed, with highest levels in brain, testis and ovary, followed by lung. {ECO:0000269|PubMed:10231032}.

FBL11 CRISPR/Cas9 KO Plasmid (h) - sc-409234 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL11 HDR Plasmid (h) - sc-409234-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL11 Double Nickase Plasmid (h) - sc-409234-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL11 Double Nickase Plasmid (h2) - sc-409234-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL11 CRISPR Activation Plasmid (h) - sc-409234-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL11 CRISPR Activation Plasmid (h2) - sc-409234-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL11 Lentiviral Activation Particles (h) - sc-409234-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL11 Lentiviral Activation Particles (h2) - sc-409234-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL11 siRNA (h) - sc-96991 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBL11 shRNA Plasmid (h) - sc-96991-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBL11 shRNA (h) Lentiviral Particles - sc-96991-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KDM2A/FBXL11 RNAi - H00022992-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU154671 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11026 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11026 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11652 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11652

KDM2A siRNA (Human) - CRH7914 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KDM2A (NM_012308.2) - SHH324147 from Creative biogene

Category siRNA
Species Reactivities Human

KDM2A shRNA Plasmid (Human) - CHH7914 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KDM2A miRNA 3'UTR clone - MiUTR4H-TG04753 from Creative biogene

Species Reactivities Human
Search more