KDM2A

Gene Symbol	KDM2A
Entrez Gene	22992
Alt Symbol	CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
Species	Human
Gene Type	protein-coding
Description	lysine (K)-specific demethylase 2A
Other Description	CXXC-type zinc finger protein 8|F-box and leucine-rich repeat protein 11|F-box/LRR-repeat protein 11|[Histone-H3]-lysine-36 demethylase 1A|jmjC domain-containing histone demethylation protein 1A|jumonji C domain-containing histone demethylase 1A|lysine-specific demethylase 2A
Swissprots	Q69YY8 Q4G0M3 I3VM55 E9PIL6 Q9UK66 D4QA03 Q9BVH5 Q9Y2K7 Q9H7H5 Q49A21
Accessions	CCO13754 EAW74578 EAW74579 EAW74580 Q9Y2K7 AB023221 BAA76848 AB490246 BAJ05817 AF179221 AAD56012 AI185920 AK022684 AK024505 BAB15795 AK128293 AK299725 BAG61623 AL117517 CAH10721 BC001203 AAH01203 BC027467 BC047371 AAH47371 BC047486 AAH47486 BC056905 BC064360 AAH64360 BE675843 DR001963 JQ710741 AFK81540 JQ710742 AFK81541 JQ710743 AFK81542 JQ710744 AFK81543 XM_006718479 XP_006718542 XM_006718480 XP_006718543 XM_011544860 XP_011543162 XM_011544861 XP_011543163 XM_011544862 XP_011543164 NM_001256405 NP_001243334 NM_012308 NP_036440 NR_027473
Function	Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877}.
Subcellular Location	Nucleus, nucleoplasm {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.
Tissue Specificity	Widely expressed, with highest levels in brain, testis and ovary, followed by lung. {ECO:0000269|PubMed:10231032}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FBXL11 peptide - ab30408 from Abcam Category Peptide

Human FBXL11 peptide - ab48669 from Abcam Category Peptide

Human FBXL11 protein fragment - ab151923 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human FBXL11 protein fragment - ab161493 from Abcam Category Protein Source Wheat germ Species Human

JHDM1A / KDM2A Blocking Peptide - LS-E213 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JHDM1A / KDM2A Antibody Blocking Peptide - LS-E214 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JHDM1A / KDM2A Antibody Blocking Peptide - LS-E27677 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JHDM1A / KDM2A Antibody Blocking Peptide - LS-E11080 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human KDM2A/FBXL11 Protein - H00022992-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KDM2A/FBXL11 Peptide - P0172 from Novus Biologicals Category Peptide Species Human

KDM2A/FBXL11 Peptide - P0171 from Novus Biologicals Category Peptide Species Human

JHDM1aFBXL11-Antibody-Center-Blocking-Peptide - BP1043c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JHDM1aFBXL11-Antibody-N-term-Blocking-Peptide - BP1043a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FBXL11 Blocking Peptide - 33R-7980 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FBXL11 Peptide - AC21-2493-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

KDM2A / FBXL11 - H00022992-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KDM2A / FBXL11 - H00022992-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

KDM2A Peptide - 42-851P from ProSci Category Peptide Species Human

KDM2A fusion protein - Ag19448 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

KDM2A fusion protein - Ag19467 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant KDM2A / FBXL11 protein - 31485 from ActiveMotif Category Protein Prices $395.00 Sizes 20 µg Source Baculovirus Species Human

Recombinant Human KDM2A, GST-tagged - KDM2A-213H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human KDM2A, GST-tagged - KDM2A-300H from Creative Biomart Category Protein Source E.coli Species Human

KDM2A protein-GST fusion - 009-001-S32 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

KDM2A protein-GST fusion - 009-001-S32S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

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