ITK

Gene Symbol	ITK
Entrez Gene	3702
Alt Symbol	EMT, LPFS1, LYK, PSCTK2
Species	Human
Gene Type	protein-coding
Description	IL2-inducible T-cell kinase
Other Description	IL-2-inducible T cell kinase|IL-2-inducible T-cell kinase|T-cell-specific kinase|homolog of mouse T-cell itk/tsk|interleukin-2-inducible T cell kinase|interleukin-2-inducible T-cell kinase|kinase EMT|tyrosine-protein kinase ITK/TSK|tyrosine-protein kinase LYK
Swissprots	B2R752 Q32ML7 Q08881
Accessions	EAW61608 Q08881 AB209622 BAD92859 AK303609 BAG64622 AK311654 AK312846 BAG35699 BC094701 BC109077 AAI09078 BC109078 AAI09079 BX538196 CAD98063 D13720 BAA02873 NM_005546 NP_005537
Function	Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ulti
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17060314}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.
Tissue Specificity	T-cell lines and natural killer cell lines.
Top Pathways	T cell receptor signaling pathway, Leukocyte transendothelial migration, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse ITK / EMT ELISA Kit (Sandwich ELISA) - LS-F8619 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.107 ng/ml Range 0.313-20 ng/ml

Phosphotyrosine ITK / Tyrosine-protein Kinase ITK/TSK ELISA Kit - RAB0969 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

ITK (Human) IP-WB Antibody Pair - H00003702-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

IL2 Inducible T-Cell Kinase (ITK), ELISA Kit - MBS2021460 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.107ng/mL. Range 0.313-20ng/mL

IL2-inducible T-cell kinase - MBS9310723 from MyBioSource Category ELISA Kit Prices $435.00, $600.00 Sizes 48 strip wells, 96 strip wells

ELISA Kit for IL2 Inducible T-Cell Kinase (ITK) - SEH774Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.107ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Phosphotyrosine ITK ELISA - PEL-ITK-Y-1 from RayBiotech Category ELISA Kit Prices $398.00, $716.40, $1,592.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human ITK ELISA Kit - E020883 from Biobool Category ELISA Kit

anti-ITK antibody - ARG63136 from Arigo Biolaboratories Category ELISA Kit

anti-ITK antibody [2F12] - ARG62525 from Arigo Biolaboratories Category ELISA Kit

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