ITK

Gene Symbol	ITK
Entrez Gene	3702
Alt Symbol	EMT, LPFS1, LYK, PSCTK2
Species	Human
Gene Type	protein-coding
Description	IL2-inducible T-cell kinase
Other Description	IL-2-inducible T cell kinase|IL-2-inducible T-cell kinase|T-cell-specific kinase|homolog of mouse T-cell itk/tsk|interleukin-2-inducible T cell kinase|interleukin-2-inducible T-cell kinase|kinase EMT|tyrosine-protein kinase ITK/TSK|tyrosine-protein kinase LYK
Swissprots	B2R752 Q32ML7 Q08881
Accessions	EAW61608 Q08881 AB209622 BAD92859 AK303609 BAG64622 AK311654 AK312846 BAG35699 BC094701 BC109077 AAI09078 BC109078 AAI09079 BX538196 CAD98063 D13720 BAA02873 NM_005546 NP_005537
Function	Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ulti
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17060314}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.
Tissue Specificity	T-cell lines and natural killer cell lines.
Top Pathways	T cell receptor signaling pathway, Leukocyte transendothelial migration, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ITK protein fragment - ab79617 from Abcam Category Protein Prices $343.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active ITK protein fragment - ab60300 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells

Active mouse ITK protein fragment - ab196118 from Abcam Category Protein Prices $612.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Mouse

Active rat ITK protein fragment - ab196125 from Abcam Category Protein Prices $891.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Rat

Human ITK full length protein - ab131804 from Abcam Category Protein Source Wheat germ Species Human

Human ITK peptide - ab23164 from Abcam Category Peptide Species Human

Human ITK protein fragment - ab152482 from Abcam Category Protein Source Wheat germ Species Human

ITK / EMT Antibody Blocking Peptide - LS-E5087 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITK / EMT Antibody Blocking Peptide - LS-E25228 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITK / EMT Antibody Blocking Peptide - LS-E9214 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITK / EMT Antibody Blocking Peptide - LS-E26818 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ITK Protein - H00003702-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ITK Protein - H00003702-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

ITK Recombinant Protein - P3870 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

ITK Recombinant Protein - P4707 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

ITK Peptide - P2754 from Novus Biologicals Category Peptide Species Human

ITK-Antibody-N-term-Blocking-Peptide - BP17502a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ITK-Antibody-Center-Blocking-Peptide - BP7711c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ITK blocking peptide - GTX89987-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

Recombinant Human Active ITK (aa 352-620), CF - 4587-KS-010 from R&D Systems Category Protein

ITK Peptide - AC21-0052-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ITK Peptide - AC21-2814-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Tyrosine-protein kinase ITK/TSK - H00003702-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Tyrosine-protein kinase ITK/TSK - H00003702-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Tyrosine-protein kinase ITK/TSK - H00003702-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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