| Gene Symbol |
COMMD3
|
| Entrez Gene |
23412
|
| Alt Symbol |
BUP, C10orf8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
COMM domain containing 3
|
| Other Description |
COMM domain-containing protein 3|protein Bup
|
| Swissprots |
Q5T8Y9 D3DRU7 Q9UBI1
|
| Accessions |
EAW86149 EAW86155 Q9UBI1 AF078848 AAD44480 AF201948 AAF17240 AK128789 BAG54735 AW169042 AY542159 AAS22241 BC022898 AAH22898 BF695081 BG496810 BQ930333 BX647275 NM_012071 NP_036203
|
| Function |
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:23637203, ECO:0000305|PubMed:21778237}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
|
| Tissue Specificity |
Widely expressed with highest expression in thymus. {ECO:0000269|PubMed:15799966}.
|
![Western Blot: COMMD3 Overexpression Lysate (Adult Normal) [NBL1-09368] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for COMMD3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6684_COMMD3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09368-img0002.jpg)