Gene Symbol | COMMD3 |
---|---|
Entrez Gene | 23412 |
Alt Symbol | BUP, C10orf8 |
Species | Human |
Gene Type | protein-coding |
Description | COMM domain containing 3 |
Other Description | COMM domain-containing protein 3|protein Bup |
Swissprots | Q5T8Y9 D3DRU7 Q9UBI1 |
Accessions | EAW86149 EAW86155 Q9UBI1 AF078848 AAD44480 AF201948 AAF17240 AK128789 BAG54735 AW169042 AY542159 AAS22241 BC022898 AAH22898 BF695081 BG496810 BQ930333 BX647275 NM_012071 NP_036203 |
Function | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:23637203, ECO:0000305|PubMed:21778237}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}. |
Tissue Specificity | Widely expressed with highest expression in thymus. {ECO:0000269|PubMed:15799966}. |