Gene Symbol | COMMD3 |
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Entrez Gene | 23412 |
Alt Symbol | BUP, C10orf8 |
Species | Human |
Gene Type | protein-coding |
Description | COMM domain containing 3 |
Other Description | COMM domain-containing protein 3|protein Bup |
Swissprots | Q5T8Y9 D3DRU7 Q9UBI1 |
Accessions | EAW86149 EAW86155 Q9UBI1 AF078848 AAD44480 AF201948 AAF17240 AK128789 BAG54735 AW169042 AY542159 AAS22241 BC022898 AAH22898 BF695081 BG496810 BQ930333 BX647275 NM_012071 NP_036203 |
Function | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:23637203, ECO:0000305|PubMed:21778237}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}. |
Tissue Specificity | Widely expressed with highest expression in thymus. {ECO:0000269|PubMed:15799966}. |
COMMD3 CRISPR/Cas9 KO Plasmid (h) - sc-411735 from Santa Cruz Biotechnology
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COMMD3 HDR Plasmid (h) - sc-411735-HDR from Santa Cruz Biotechnology
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COMMD3 Double Nickase Plasmid (h) - sc-411735-NIC from Santa Cruz Biotechnology
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COMMD3 Double Nickase Plasmid (h2) - sc-411735-NIC-2 from Santa Cruz Biotechnology
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COMMD3 CRISPR Activation Plasmid (h) - sc-411735-ACT from Santa Cruz Biotechnology
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COMMD3 CRISPR Activation Plasmid (h2) - sc-411735-ACT-2 from Santa Cruz Biotechnology
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COMMD3 Lentiviral Activation Particles (h) - sc-411735-LAC from Santa Cruz Biotechnology
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COMMD3 Lentiviral Activation Particles (h2) - sc-411735-LAC-2 from Santa Cruz Biotechnology
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COMMD3 siRNA (h) - sc-90821 from Santa Cruz Biotechnology
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COMMD3 shRNA Plasmid (h) - sc-90821-SH from Santa Cruz Biotechnology
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COMMD3 shRNA (h) Lentiviral Particles - sc-90821-V from Santa Cruz Biotechnology
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COMMD3 RNAi - H00023412-R02 from Novus Biologicals
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MISSION® esiRNA - EHU004891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6416 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6416 from Sigma-Aldrich
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COMMD3 siRNA (Human) - CRH8251 from Cohesion Biosciences
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COMMD3 - MBS828627 from MyBioSource
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shRNA set against Human COMMD3 (NM_012071.3) - SHH267593 from Creative biogene
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COMMD3 shRNA Plasmid (Human) - CHH8251 from Cohesion Biosciences
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COMMD3 miRNA 3'UTR clone - MiUTR3H-14492 from Creative biogene
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