| Gene Symbol |
TEAD3
|
| Entrez Gene |
7005
|
| Alt Symbol |
DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, TEF5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TEA domain family member 3
|
| Other Description |
TEA domain family member 5|transcriptional enhancer factor 5|transcriptional enhancer factor TEF-5|transcriptional enhancer factor TEF-5 (DTEF-1)
|
| Swissprots |
Q5BJG7 Q99594 Q8N6Y4 O95910
|
| Accessions |
EAX03835 EAX03836 EAX03837 EAX03838 Q99594 AF142482 AAD29052 AK226144 BC010053 AAH10053 BC027877 AAH27877 BC091488 AAH91488 BQ719548 DA856821 JF432847 ADZ16064 X94439 CAA64213 NM_003214 NP_003205
|
| Function |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Preferentially expressed in the placenta.
|
| Top Pathways |
Hippo signaling pathway
|