NANOS2

Gene Symbol NANOS2
Entrez Gene 339345
Alt Symbol NOS2
Species Human
Gene Type protein-coding
Description nanos homolog 2 (Drosophila)
Other Description NOS-2|nanos homolog 2
Swissprots Q17R30 Q4G0P8 P60321
Accessions P60321 BC042883 AAH42883 BC117484 AAI17485 BC117486 AAI17487 HQ258065 ADR82819 NM_001029861 NP_001025032
Function Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19168545}. Cytoplasm, P-body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168545}. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. {ECO:0000250}.
Tissue Specificity Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level). {ECO:0000269|PubMed:19168545, ECO:0000269|PubMed:21421998}.

Nanos2 (A-8) - sc-393868 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Nanos2 (A-8): sc-393868. Western blot analysis of human recombinant Nanos2 fusion protein.

Nanos2 (B-12) - sc-393794 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Nanos2 (B-12): sc-393794. Western blot analysis of human recombinant Nanos2 fusion protein.

Nanos2 (A-12) - sc-69187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Nanos2 (G-20) - sc-69188 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Nanos2 (G-20): sc-69188. Western blot analysis of human recombinant Nanos2 fusion protein.

Nanos2 (H-64) - sc-292082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Nanos2 (S-16) - sc-69190 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Nanos2 (S-16): sc-69190. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining of cells in seminiferous ducts and Leydig cells.

Anti-NANOS2 antibody - ab76568 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin fixed and paraffin embedded human testis tissue stained with ab76568 at 1/10 dilution, followed by treatment with a peroxidase conjugated secondary antibody and DAB staining.

Anti-NANOS2 antibody - ab70000 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NANOS2 antibody (ab70000) at 2 µg/ml + SK-N-SH cell lysate at 15 µg

Anti-NANOS2 antibody - ab174139 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NANOS2 antibody (ab174139) at 1/100 dilutionLane 1 : 293 cell lysate, non-transfectedLane 2 : 293 cell lysate, transiently transfected with NANOS2Lysates/proteins at 2 µg per lane.

Anti-NANOS2 antibody - ab169436 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-NANOS2 antibody (ab169436) at 1 µg/mlLane 1 : NANOS2 transfected lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.

Anti-NANOS2 antibody - C-terminal - ab186901 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NANOS2 antibody - C-terminal (ab186901) at 1 µg/ml + Jurkat whole cell lysate at 10 µg

Anti-NANOS2 / NOS2 Antibody (aa1-173) - LS-C73159 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-NANOS2 / NOS2 Antibody (aa57-85, APC) - LS-C237907 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NANOS2 / NOS2 Antibody (aa57-85, AP) - LS-C237905 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NANOS2 / NOS2 Antibody (aa57-85, Biotin) - LS-C237908 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NANOS2 / NOS2 Antibody (aa57-85, FITC) - LS-C237909 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NANOS2 / NOS2 Antibody (aa57-85, PE) - LS-C237912 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NANOS2 / NOS2 Antibody (aa57-85, Azide-free, HRP) - LS-C248881 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NANOS2 / NOS2 Antibody (aa57-85) - LS-C329867 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NANOS2 / NOS2 Antibody (C-Terminus) - LS-C53317 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 50 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of Nanos2 in SK-N-SH cell lysate with Nanos2 antibody at 2 ug/ml.

Anti-NANOS2 / NOS2 Antibody (aa83-132) - LS-C206180 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NANOS2 / NOS2 antibody Western Blot of Jurkat. Antibody dilution: 1 ug/ml.

Anti-NANOS2 / NOS2 Antibody (aa58-85) - LS-C158355 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of NANOS2 (arrow) using rabbit polyclonal NANOS2 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the NANOS2 gene.

Anti-NANOS2 / NOS2 Antibody (aa108-137) - LS-C98598 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human testis tissue reacted with NANOS2 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-NANOS2 / NOS2 Antibody (N-Terminus) - LS-C53318 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 50 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of Nanos2 in Human Testis cells with Nanos2 antibody at 20 ug/ml.

Nanos2 Antibody (343255) - MAB2870 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 343255
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