NANOS2
| Gene Symbol | NANOS2 |
|---|---|
| Entrez Gene | 339345 |
| Alt Symbol | NOS2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nanos homolog 2 (Drosophila) |
| Other Description | NOS-2|nanos homolog 2 |
| Swissprots | Q17R30 Q4G0P8 P60321 |
| Accessions | P60321 BC042883 AAH42883 BC117484 AAI17485 BC117486 AAI17487 HQ258065 ADR82819 NM_001029861 NP_001025032 |
| Function | Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19168545}. Cytoplasm, P-body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168545}. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. {ECO:0000250}. |
| Tissue Specificity | Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level). {ECO:0000269|PubMed:19168545, ECO:0000269|PubMed:21421998}. |
Nanos2 CRISPR/Cas9 KO Plasmid (h) - sc-404123 from Santa Cruz Biotechnology
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Nanos2 HDR Plasmid (h) - sc-404123-HDR from Santa Cruz Biotechnology
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Nanos2 Double Nickase Plasmid (h) - sc-404123-NIC from Santa Cruz Biotechnology
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Nanos2 Double Nickase Plasmid (h2) - sc-404123-NIC-2 from Santa Cruz Biotechnology
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Nanos2 CRISPR Activation Plasmid (h) - sc-404123-ACT from Santa Cruz Biotechnology
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Nanos2 CRISPR Activation Plasmid (h2) - sc-404123-ACT-2 from Santa Cruz Biotechnology
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Nanos2 Lentiviral Activation Particles (h) - sc-404123-LAC from Santa Cruz Biotechnology
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Nanos2 Lentiviral Activation Particles (h2) - sc-404123-LAC-2 from Santa Cruz Biotechnology
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Nanos2 siRNA (h) - sc-75866 from Santa Cruz Biotechnology
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Nanos2 shRNA Plasmid (h) - sc-75866-SH from Santa Cruz Biotechnology
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Nanos2 shRNA (h) Lentiviral Particles - sc-75866-V from Santa Cruz Biotechnology
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iNOS RNAi - H00004843-R01 from Novus Biologicals
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Nanos2 RNAi - H00339345-R01 from Novus Biologicals
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iNOS RNAi - H00004843-R02 from Novus Biologicals
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MISSION® esiRNA - EHU122481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14941 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08006 from Sigma-Aldrich
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NANOS2 siRNA (Human) - CRJ7286 from Cohesion Biosciences
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Nanos2 CRISPR/Cas9 KO Plasmid (h2) - sc-404123-KO-2 from Santa Cruz Biotechnology
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Nanos2 HDR Plasmid (h2) - sc-404123-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human NANOS2 (NM_001029861.2) - SHH349180 from Creative biogene
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shRNA set against Human NANOS2(NM_001029861.2) - SHH215381 from Creative biogene
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NANOS2 shRNA Plasmid (Human) - CHJ7286 from Cohesion Biosciences
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NANOS2 miRNA 3'UTR clone - MiUTR1H-06630 from Creative biogene
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