| Gene Symbol | NANOS2 |
|---|---|
| Entrez Gene | 339345 |
| Alt Symbol | NOS2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nanos homolog 2 (Drosophila) |
| Other Description | NOS-2|nanos homolog 2 |
| Swissprots | Q17R30 Q4G0P8 P60321 |
| Accessions | P60321 BC042883 AAH42883 BC117484 AAI17485 BC117486 AAI17487 HQ258065 ADR82819 NM_001029861 NP_001025032 |
| Function | Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19168545}. Cytoplasm, P-body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168545}. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. {ECO:0000250}. |
| Tissue Specificity | Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level). {ECO:0000269|PubMed:19168545, ECO:0000269|PubMed:21421998}. |