Gene Symbol | Sox2 |
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Entrez Gene | 20674 |
Alt Symbol | Sox-2, lcc, ysb |
Species | Mouse |
Gene Type | protein-coding |
Description | SRY (sex determining region Y)-box 2 |
Other Description | SRY-box containing gene 2|transcription factor SOX-2 |
Swissprots | P48432 |
Accessions | CAA63847 EDL35051 P48432 AB108673 BAC75668 AB221649 AK131933 BAE20882 AK149358 BAE28833 BC057574 AAH57574 BY713734 CD353783 CD354017 U31967 AAC31791 NM_011443 NP_035573 |
Function | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:17097055}. |
Tissue Specificity | Expressed in the brain and retina. A very low level expression is seen in the stomach and lung. Expressed in developing urogenital ridge. |
Top Pathways | Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells |
Transcription factor SOX-2 (SOX2), Mouse, ELISA Kit - CSB-EL022426MO from ARP American Research Products
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Transcription factor SOX-2 (SOX2), Mouse, ELISA Kit - E03T0646 from ARP American Research Products
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Transcription factor SOX-2, Sox2, Mouse, ELISA Kit - E0423m from ARP American Research Products
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Mouse SOX2 ELISA Kit - MS0155 from NeoScientific
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SRY (sex determining region Y) -box 2, ELISA Kit - MBS925992 from MyBioSource
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Mouse Transcription factor SOX-2(SOX2) ELISA kit - CSB-EL022426MO from Cusabio
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Mouse Sex Determining Region Y Box Protein 2 ELISA - E03S0148 from BlueGene Biotech
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Mouse Transcription factor SOX-2 (SOX2) ELISA Kit - EKC37944 from Biomatik
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Mouse Sox2 ELISA Kit - E067597 from Biobool
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Mouse SOX2 ELISA Kit - EMS0155 from ABclonal
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Transcription factor SOX-2, ELISA Kit - MBS2882015 from MyBioSource
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SOX2 ELISA Kit (Mouse) (OKCA02467) - OKCA02467 from Aviva Systems Biology
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SimpleChIP ® Mouse Sox2 Exon1 Primers - 30180 from Cell Signaling Technology
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