| Gene Symbol |
Sox2
|
| Entrez Gene |
20674
|
| Alt Symbol |
Sox-2, lcc, ysb
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
SRY (sex determining region Y)-box 2
|
| Other Description |
SRY-box containing gene 2|transcription factor SOX-2
|
| Swissprots |
P48432
|
| Accessions |
CAA63847 EDL35051 P48432 AB108673 BAC75668 AB221649 AK131933 BAE20882 AK149358 BAE28833 BC057574 AAH57574 BY713734 CD353783 CD354017 U31967 AAC31791 NM_011443 NP_035573
|
| Function |
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:17097055}.
|
| Tissue Specificity |
Expressed in the brain and retina. A very low level expression is seen in the stomach and lung. Expressed in developing urogenital ridge.
|
| Top Pathways |
Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells
|