PPM1L

Gene Symbol PPM1L
Entrez Gene 151742
Alt Symbol PP2C-epsilon, PP2CE, PPM1-LIKE
Species Human
Gene Type protein-coding
Description protein phosphatase, Mg2+/Mn2+ dependent, 1L
Other Description PP2C epsilon|Protein phosphatase 2C epsilon isoform|protein phosphatase 1L|protein phosphatase 2C isoform epsilon
Swissprots Q96NM7 Q2M3J2 Q5SGD2
Accessions EAW78626 Q5SGD2 AK055115 BAB70856 AK055323 AK055510 AK092378 AY337264 AAR00269 BC035116 BC090872 BC104885 AAI04886 BC104887 AAI04888 BC110801 XM_006713507 XP_006713570 XM_011512440 XP_011510742 XM_011512441 XP_011510743 NM_139245 NP_640338
Function Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. {ECO:0000269|PubMed:17456047}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas. {ECO:0000269|PubMed:15560375}.

Anti-PPM1L antibody - ab107642 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PPM1L antibody (ab107642) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

Anti-PPM1L antibody - ab137931 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PPM1L antibody (ab137931) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-PPM1L antibody - ab139713 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PPM1L antibody (ab139713) at 1 µg/ml + HepG2 whole cell lysate at 10 µg

Anti-PPM1L Antibody (aa215-244, FITC) - LS-C239351 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1L Antibody (aa215-244, APC) - LS-C239350 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1L Antibody (aa102-151) - LS-C200509 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HepG2 cells using PPM1L antibody.

Anti-PPM1L Antibody (aa215-244, PE) - LS-C239352 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1L Antibody (aa215-244, Azide-free, HRP) - LS-C248532 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1L Antibody (aa119-168) - LS-C120265 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, using PPM1L Antibody. The lane on the right is treated with the synthesized peptide.

Anti-PPM1L Antibody (aa215-244) - LS-C324229 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1L Antibody (aa141-190) - LS-C170027 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PPM1L Antibody (aa215-244) - LS-C162074 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PPM1L antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lung tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-PPM1L Antibody (aa215-244, AP) - LS-C239348 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1L Antibody (aa215-244, Biotin) - LS-C239349 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

PP2C epsilon/PPM1L Antibody (700612) - MAB6914 from Novus Biologicals

Prices $249.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 700612
Western Blot PP2C epsilon/PPM1L Antibody (700612)

PP2C epsilon/PPM1L Antibody - NBP1-87247 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PP2C epsilon/PPM1L Antibody [NBP1-87247] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

PP2C epsilon/PPM1L Antibody - NBP1-87248 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1L antibody produced in rabbit - HPA019953 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PPM1L: <B>Cat. No. HPA019953</B>: Immunohistochemical staining of human skeletal muscle shows heterogeneous cytoplasmic positivity in myocytes.

Anti-PPM1L antibody produced in rabbit - SAB4500564 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PPM1L: <B>Cat. No. SAB4500564</B>: Immunoblotting analysis of extracts from Jurkat cells, using Anti-PPM1L antibody. The lane on the left was treated with the Anti-PPM1L antibody. The lane on the right (negative control) was treated with both Anti-PPM1L antibody and the synthesized immunogen peptide.

Anti-PPM1L antibody produced in rabbit - HPA019891 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PPM1L: <B>Cat. No. HPA019891</B>: Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in decidual cells.

PPM1L Antibody - middle region (ARP67754_P050) - ARP67754_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PPM1L Antibody - C-terminal region (OAAB01021) - OAAB01021 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PPM1L-Antibody-C-term - AP11001b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
PPM1L Antibody (C-term) (Cat. #AP11001b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the PPM1L antibody detected the PPM1L protein (arrow).

Human/Mouse/Rat PP2C epsilon /PPM1L Antibody - MAB6914 from R&D Systems

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clone 700612
Detection of Human, Mouse, and Rat PP2C e/PPM1L by Western Blot. Western blot shows lysates of BJAB human Burkitt's lymphoma cell line, Nb2-11 rat lymphoma cell line, Neuro-2A mouse neuroblastoma cell line, and L1.2 mouse pro-B cell line. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human PP2C e/PPM1L Monoclonal Antibody (Catalog # MAB6914) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007 ). A specific band was detected for PP2C e/PPM1L at approximately 35 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1 .

Human/Mouse/Rat PP2C epsilon/PPM1L MAb (Clone 700612), Mouse IgG2B - MAB6914-SP from R&D Systems

Host Mouse
Clonality Monoclonal
Clone 700612
Detection of Human, Mouse, and Rat PP2C  epsilon/PPM1L by Western Blot. Western blot shows lysates of BJAB human Burkitt's lymphoma cell line, Nb2‑11 rat lymphoma cell line, Neuro‑2A mouse neuroblastoma cell line, and L1.2 mouse pro-B cell line. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human PP2C  epsilon/PPM1L Monoclonal Antibody (Catalog # MAB6914) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PP2C  epsilon/PPM1L at approximately 35 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
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