ELOVL1

Gene Symbol ELOVL1
Entrez Gene 64834
Alt Symbol CGI-88, Ssc1
Species Human
Gene Type protein-coding
Description ELOVL fatty acid elongase 1
Other Description 3-keto acyl-CoA synthase ELOVL1|ELOVL FA elongase 1|elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1|elongation of very long chain fatty acids protein 1|very-long-chain 3-oxoacyl-CoA synthase 1
Swissprots Q5JUY3 Q9NVD9 B4DP24 Q9Y396 Q8WXU3 Q53HT2 Q9BW60
Accessions EAX07100 Q9BW60 AA635780 AF151846 AAD34083 AF336793 AAL71993 AK001653 BAA91813 AK130174 AK222498 BAD96218 AK298163 BAG60436 AL537185 BC000618 AAH00618 BC095456 AAH95456 BM556982 BP208926 BP281965 BU180063 BU786323 BU857779 CB149715 NM_001256399 NP_001243328 NM_001256401 NP_001243330 NM_001256402 NP_001243331 NM_022821 NP_073732 NR_046117
Function Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. {ECO:0000269|PubMed:20166112, ECO:0000269|PubMed:20937905}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:20937905}.
Top Pathways Fatty acid elongation

ELOVL1 (N-15) - sc-54870 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ELOVL1 (N-15): sc-54870. Western blot analysis of ELOVL1 expression in Hep G2 (A), CCD-1064Sk (B), Y79 (C), IMR-32 (D), A-375 (E) and SK-N-MC (F) whole cell lysates.

ELOVL1 (H-65) - sc-135058 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ELOVL1 (H-65): sc-135058. Western blot analysis of ELOVL1 expression in mouse brain tissue extract.

Anti-ELOVL1 antibody - ab74941 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ELOVL1 antibody (ab74941) at 1/500 dilutionLane 1 : Extracts from HepG2 cellsLane 2 : Extracts from Jurkat cellsLane 3 : Extracts from Jurkat cells with immunizing peptide at 5 µgLysates/proteins at 15 µg per lane.

Anti-ELOVL1 antibody - N-terminal - ab173656 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ELOVL1 antibody - N-terminal (ab173656) at 1/100 dilution + HeLa cell lysate at 35 µg

Anti-ELOVL1 Antibody (aa1-30, AP) - LS-C256645 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL1 Antibody (aa1-30, APC) - LS-C256646 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL1 Antibody (aa1-30, Biotin) - LS-C256647 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL1 Antibody (aa1-30, Azide-free, HRP) - LS-C256648 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL1 Antibody (aa1-30, FITC) - LS-C256649 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL1 Antibody (aa1-30, PE) - LS-C259257 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL1 Antibody (aa1-30) - LS-C321093 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL1 Antibody (aa101-150) - LS-C119951 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat/HepG2 cells, using ELOVL1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-ELOVL1 Antibody (Phe139) - LS-C177370 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ELOVL1 (F139) pAb in extracts from Jurkat cells.

Anti-ELOVL1 Antibody (aa1-30) - LS-C159525 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ELOVL1 Antibody western blot of HeLa cell line lysates (35 ug/lane). The ELOVL1 antibody detected the ELOVL1 protein (arrow).

Anti-ELOVL1 Antibody (N-Terminus) - LS-C345478 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of ELOV1 Antibody with human Stomach Tumor lysate.

ELOVL1 Antibody - NBP1-68492 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: ELOVL1 Antibody [NBP1-68492] - Analysis of extracts from Jurkat/HepG2 cells, using ELOVL1 Antibody. The lane on the right is treated with the synthesized peptide.

ELOVL1 Antibody - NBP1-00800 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: ELOVL1 Antibody [NBP1-00800] - Western blot (WB) analysis of ELOVL1 (F139) antibody in extracts from Jurkat cells.

ELOVL1 Antibody - NBP2-37956 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: ELOVL1 Antibody [NBP2-37956] - Staining of human stomach shows moderate cytoplasmic positivity in glandular cells.

fatty acid elongase Polyclonal Antibody - bs-2260R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ELOVL1 antibody produced in rabbit - SAB4502782 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ELOVL1: <B>Cat. No. SAB4502782</B>: Immunoblotting analysis of extracts from Jurkat/HepG2 cells, using Anti-ELOVL1 antibody. The lane on the left was treated with the Anti-ELOVL1 antibody. The lane on the right (negative control) was treated with both Anti-ELOVL1 antibody and the synthesized immunogen peptide.

Anti-ELOVL1 antibody produced in rabbit - SAB4300768 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ELOVL1: <B>Cat. No. SAB4300768</B>: Western blot analysis of extracts from HepG2 cells and Jurkat cells using Anti-ELOVL1 antibody. The lane on the right is treated with the synthesized peptide.

ANTI-ELOVL1 (N-TERM) antibody produced in rabbit - SAB1304449 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ELOVL1 (N-term): <B>Cat. No. SAB1304449</B>: ELOVL1 Antibody (N-term) western blot analysis in HeLa cell line lysates (35 μg/lane).

ELOV1 Antibody - N-terminal region (ARP49759_P050) - ARP49759_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ELOVL1-Antibody-N-term - AP17913a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
ELOVL1 Antibody (N-term) (Cat. #AP17913a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the ELOVL1 antibody detected the ELOVL1 protein (arrow).

ELOVL1-Antibody - AP50613 from Abgent, a WuXi AppTec company

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysate from human spleen tissue lysate,using ELOVL1 Antibody(AP50613). AP50613 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
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