ELOVL1

Gene Symbol	ELOVL1
Entrez Gene	64834
Alt Symbol	CGI-88, Ssc1
Species	Human
Gene Type	protein-coding
Description	ELOVL fatty acid elongase 1
Other Description	3-keto acyl-CoA synthase ELOVL1|ELOVL FA elongase 1|elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1|elongation of very long chain fatty acids protein 1|very-long-chain 3-oxoacyl-CoA synthase 1
Swissprots	Q5JUY3 Q9NVD9 B4DP24 Q9Y396 Q8WXU3 Q53HT2 Q9BW60
Accessions	EAX07100 Q9BW60 AA635780 AF151846 AAD34083 AF336793 AAL71993 AK001653 BAA91813 AK130174 AK222498 BAD96218 AK298163 BAG60436 AL537185 BC000618 AAH00618 BC095456 AAH95456 BM556982 BP208926 BP281965 BU180063 BU786323 BU857779 CB149715 NM_001256399 NP_001243328 NM_001256401 NP_001243330 NM_001256402 NP_001243331 NM_022821 NP_073732 NR_046117
Function	Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. {ECO:0000269|PubMed:20166112, ECO:0000269|PubMed:20937905}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:20937905}.
Top Pathways	Fatty acid elongation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ELOVL1 Antibody Blocking Peptide - LS-E5404 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELOVL1-Antibody-N-term-Blocking-Peptide - BP17913a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ELOVL1 fusion protein - ag14144 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ELOVL1 fusion protein - ag14457 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Elongation Of Very Long Chain Fatty Acids Like Protein 1 (ELOVL1) - RPJ169Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Elongation Of Very Long Chain Fatty Acids Like Protein 1 (ELOVL1) - RPJ169Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

ELOVL1 Blocking Peptide - CBP3430 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

ELOVL1 (F139) Peptide - BS3121P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Elongation Of Very Long Chain Fatty Acids Like Protein 1 (ELOVL1) - RPJ169Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Aquaporin 9 (AQP9) - RPA578Hu01 from Cloud-clone Category Protein Source E.coli Species Human

ELOVL1 Protein - NBP2-37956PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ELOVL1 Blocking Peptide - abx162292 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

ELOVL1 Peptide, Human - M34GP04875H from Creative Peptides Category Peptide Source Synthetic. Species Human

Elongation of very long chain fatty acids protein 1 (ELOVL1), Recombinant Protein - MBS7014206 from MyBioSource Category Protein Prices $1,090.00, $2,075.00, $3,285.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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