ELOVL1

Gene Symbol ELOVL1
Entrez Gene 64834
Alt Symbol CGI-88, Ssc1
Species Human
Gene Type protein-coding
Description ELOVL fatty acid elongase 1
Other Description 3-keto acyl-CoA synthase ELOVL1|ELOVL FA elongase 1|elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1|elongation of very long chain fatty acids protein 1|very-long-chain 3-oxoacyl-CoA synthase 1
Swissprots Q5JUY3 Q9NVD9 B4DP24 Q9Y396 Q8WXU3 Q53HT2 Q9BW60
Accessions EAX07100 Q9BW60 AA635780 AF151846 AAD34083 AF336793 AAL71993 AK001653 BAA91813 AK130174 AK222498 BAD96218 AK298163 BAG60436 AL537185 BC000618 AAH00618 BC095456 AAH95456 BM556982 BP208926 BP281965 BU180063 BU786323 BU857779 CB149715 NM_001256399 NP_001243328 NM_001256401 NP_001243330 NM_001256402 NP_001243331 NM_022821 NP_073732 NR_046117
Function Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. {ECO:0000269|PubMed:20166112, ECO:0000269|PubMed:20937905}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:20937905}.
Top Pathways Fatty acid elongation

ELOVL1 overexpression lysate - LY411528 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

ELOVL1 Overexpression Lysate (Native) - NBP2-06398 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: ELOVL1 Overexpression Lysate (Adult Normal) [NBP2-06398] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ELOVL1.

Panoply™ Human ELOVL1 Knockdown Stable Cell Line - CSC-DC004875 from Creative biogene

Category Cell Line
Species Human
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