| Gene Symbol |
UBR2
|
| Entrez Gene |
23304
|
| Alt Symbol |
C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin protein ligase E3 component n-recognin 2
|
| Other Description |
E3 ubiquitin-protein ligase UBR2|ubiquitin-protein ligase E3-alpha-2|ubiquitin-protein ligase E3-alpha-II
|
| Swissprots |
Q4VXK2 O15057 Q6ZUD0 Q5TFH6 Q8IWV8 Q6P2I2
|
| Accessions |
EAX04094 EAX04095 EAX04096 EAX04097 Q8IWV8 AB002347 BAA20806 AK026998 AK090874 AK093676 AK125795 BAC86295 AK127310 BAG54478 AK304070 BAG64977 AK310532 AY061884 AAL32101 BC024217 AAH24217 BC064512 AAH64512 BC080623 BC156045 AAI56046 BX647467 DR003057 HM370397 XM_005248965 XP_005249022 XM_005248966 XP_005249023 XM_011514438 XP_011512740 XM_011514439 XP_011512741 XM_011514440 XP_011512742 XM_011514441 XP_011512743 XM_011514442 XP_011512744 NM_001184801 NP_001171730 NM_015255 NP_056070
|
| Function |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Note=Associated with chromatin during meiosis.
|
| Tissue Specificity |
Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597}.
|