UBR2

Gene Symbol UBR2
Entrez Gene 23304
Alt Symbol C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3
Species Human
Gene Type protein-coding
Description ubiquitin protein ligase E3 component n-recognin 2
Other Description E3 ubiquitin-protein ligase UBR2|ubiquitin-protein ligase E3-alpha-2|ubiquitin-protein ligase E3-alpha-II
Swissprots Q4VXK2 O15057 Q6ZUD0 Q5TFH6 Q8IWV8 Q6P2I2
Accessions EAX04094 EAX04095 EAX04096 EAX04097 Q8IWV8 AB002347 BAA20806 AK026998 AK090874 AK093676 AK125795 BAC86295 AK127310 BAG54478 AK304070 BAG64977 AK310532 AY061884 AAL32101 BC024217 AAH24217 BC064512 AAH64512 BC080623 BC156045 AAI56046 BX647467 DR003057 HM370397 XM_005248965 XP_005249022 XM_005248966 XP_005249023 XM_011514438 XP_011512740 XM_011514439 XP_011512741 XM_011514440 XP_011512742 XM_011514441 XP_011512743 XM_011514442 XP_011512744 NM_001184801 NP_001171730 NM_015255 NP_056070
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242}.
Subcellular Location Nucleus {ECO:0000250}. Note=Associated with chromatin during meiosis.
Tissue Specificity Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597}.

Ubr2 (8H10) - sc-135594 from Santa Cruz Biotechnology

Prices $295.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Ubr2 (8H10): sc-135594. Western blot analysis of Ubr2 expression in human Ubr2 transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-UBR2 antibody - ab191505 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-UBR2 antibody (ab191505)Lane 1 : HepG2 whole cell lysateLane 2 : Mouse liver tissue lysateLane 3 : Rat liver tissue lysate

Anti-UBR2 antibody - ab168607 from Abcam

Host Rabbit
Clonality Polyclonal
Immunoprecipitation of UBR2 transfected lysate using ab168607 and Protein A Magnetic Bead, and immunoblotted with ab168607.

Anti-UBR2 antibody - ab57407 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57407 UBR2 antibody at 1ug/ml.

Anti-UBR2 antibody - ab168652 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-UBR2 antibody (ab168652) at 1/500 dilutionLane 1 : UBR2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysate Lysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-UBR2 Antibody - LS-C340975 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UBR2 Antibody - LS-C332537 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using UBR2 antibody.

Anti-UBR2 Antibody (aa314-363) - LS-C201439 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Fetal Small Intestine. UBR2 antibody dilution 1.0 ug/ml.

Anti-UBR2 Antibody (C-Terminus) - LS-C82458 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MCF7 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-UBR2 Antibody (aa1618-1631) IHC-plus™ - LS-B9517 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-UBR2 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9517 concentration 5 ug/ml.

UBR2 Antibody - NBP1-54982 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: UBR2 Antibody [NBP1-54982] - Human Fetal Brain, Antibody Dilution: 1.0 ug/ml.

UBR2 Antibody (4G4) - H00023304-M01 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4G4
Western Blot: UBR2 Antibody (4G4) [H00023304-M01] - Analysis of UBR2 expression in transfected 293T cell line by UBR2 monoclonal antibody (M01), clone 4G4.Lane 1: UBR2 transfected lysate(50 KDa).Lane 2: Non-transfected lysate.

UBR2 Antibody - NBP1-88760 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: UBR2 Antibody [NBP1-88760] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes.

UBR2 Antibody - NBP1-88759 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: UBR2 Antibody [NBP1-88759] Staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli & plasma membrane.

UBR2 Antibody - NBP1-45243 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

UBR2 Antibody - H00023304-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: UBR2 Antibody [H00023304-B01] - analysis of UBR2 expression in transfected 293T cell line by UBR2 MaxPab polyclonal antibody (B01). Lane 1: UBR2 transfected lysate (50.00 KDa). Lane 2: Non-transfected lysate.

UBR2 Antibody - H00023304-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

UBR2 Antibody - H00023304-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UBR2 Polyclonal Antibody - bs-9144R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR2 antibody produced in rabbit - SAB2102634 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-UBR2: <B>Cat. No.SAB2102634</B>: UBR2 in MCF7 cell lysate with UBR2 antibody at 1.0 μg/mL.

Anti-UBR2 antibody produced in rabbit - HPA027869 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-UBR2: <B>Cat. No. HPA027869</B>: Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.

Anti-UBR2 antibody produced in rabbit - HPA027880 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-UBR2: <B>Cat. No. HPA027880</B>: Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity.

Monoclonal Anti-UBR2, (N-terminal) antibody produced in mouse - SAB1404963 from Sigma-Aldrich

Prices $347.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 4G4
<B>Immunoblotting</B><BR/>Monoclonal Anti-UBR2: <B>Cat. No. SAB1404963</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.1 kDa using immunogen protein lysate.

Monoclonal Anti-UBR2 antibody produced in mouse - WH0023304M1 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4G4
<B>Immunoblotting</B><BR/>Monoclonal Anti-UBR2, <B>Cat. No. WH0023304M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37.11 kDa using immunogen protein lysate.

UBR2 Antibody - C-terminal region (ARP43187_P050) - ARP43187_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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