UBR2

Gene Symbol	UBR2
Entrez Gene	23304
Alt Symbol	C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3
Species	Human
Gene Type	protein-coding
Description	ubiquitin protein ligase E3 component n-recognin 2
Other Description	E3 ubiquitin-protein ligase UBR2|ubiquitin-protein ligase E3-alpha-2|ubiquitin-protein ligase E3-alpha-II
Swissprots	Q4VXK2 O15057 Q6ZUD0 Q5TFH6 Q8IWV8 Q6P2I2
Accessions	EAX04094 EAX04095 EAX04096 EAX04097 Q8IWV8 AB002347 BAA20806 AK026998 AK090874 AK093676 AK125795 BAC86295 AK127310 BAG54478 AK304070 BAG64977 AK310532 AY061884 AAL32101 BC024217 AAH24217 BC064512 AAH64512 BC080623 BC156045 AAI56046 BX647467 DR003057 HM370397 XM_005248965 XP_005249022 XM_005248966 XP_005249023 XM_011514438 XP_011512740 XM_011514439 XP_011512741 XM_011514440 XP_011512742 XM_011514441 XP_011512743 XM_011514442 XP_011512744 NM_001184801 NP_001171730 NM_015255 NP_056070
Function	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242}.
Subcellular Location	Nucleus {ECO:0000250}. Note=Associated with chromatin during meiosis.
Tissue Specificity	Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBR2 full length protein - ab161596 from Abcam Category Protein Source Wheat germ Species Human

Human UBR2 protein fragment - ab161597 from Abcam Category Protein Source Wheat germ Species Human

UBR2 Antibody Blocking Peptide - LS-E27184 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBR2 Antibody Blocking Peptide - LS-E15897 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UBR2 Protein - H00023304-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human UBR2 Protein - H00023304-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

UBR2 blocking peptide - GTX88286-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Bovine

UBR2 Immunizing peptide - orb59707 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

UBR2 peptide - orb218912 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

UBR2 Blocking Peptide - 33R-7566 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBR2 Blocking Peptide - abx064243 from Abbexa Category Peptide Species Human, Mouse, Rat

UBR2 Peptide - AC21-2004-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UBR2 - H00023304-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UBR2 - H00023304-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UBR2 - H00023304-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBR2 - H00023304-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UBR2 Peptide - 42-209P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

UBR2 fusion protein - Ag13446 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human UBR2, GST-tagged - UBR2-3561H from Creative Biomart Category Protein Source E.coli Species Human

UBR2 Blocking Peptide - CBP3049 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human E3 ubiquitin-protein ligase UBR2(UBR2) ,partial - CSB-YP809001HU CSB-EP809001HU CSB-BP809001HU CSB-MP809001HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

UBR2, Peptide - MBS425808 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog, Bovine

UBR2 Recombinant Protein Antigen - NBP1-88760PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

UBR2 Recombinant Protein Antigen - NBP1-88759PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

UBR2 Peptide, Human - M34GP17004H from Creative Peptides Category Peptide Source Synthetic. Species Human

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