UBR2

Gene Symbol	UBR2
Entrez Gene	23304
Alt Symbol	C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3
Species	Human
Gene Type	protein-coding
Description	ubiquitin protein ligase E3 component n-recognin 2
Other Description	E3 ubiquitin-protein ligase UBR2|ubiquitin-protein ligase E3-alpha-2|ubiquitin-protein ligase E3-alpha-II
Swissprots	Q4VXK2 O15057 Q6ZUD0 Q5TFH6 Q8IWV8 Q6P2I2
Accessions	EAX04094 EAX04095 EAX04096 EAX04097 Q8IWV8 AB002347 BAA20806 AK026998 AK090874 AK093676 AK125795 BAC86295 AK127310 BAG54478 AK304070 BAG64977 AK310532 AY061884 AAL32101 BC024217 AAH24217 BC064512 AAH64512 BC080623 BC156045 AAI56046 BX647467 DR003057 HM370397 XM_005248965 XP_005249022 XM_005248966 XP_005249023 XM_011514438 XP_011512740 XM_011514439 XP_011512741 XM_011514440 XP_011512742 XM_011514441 XP_011512743 XM_011514442 XP_011512744 NM_001184801 NP_001171730 NM_015255 NP_056070
Function	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242}.
Subcellular Location	Nucleus {ECO:0000250}. Note=Associated with chromatin during meiosis.
Tissue Specificity	Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Ubr2 CRISPR/Cas9 KO Plasmid (h) - sc-406744 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr2 HDR Plasmid (h) - sc-406744-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr2 Double Nickase Plasmid (h) - sc-406744-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr2 Double Nickase Plasmid (h2) - sc-406744-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr2 CRISPR Activation Plasmid (h) - sc-406744-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr2 CRISPR Activation Plasmid (h2) - sc-406744-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr2 Lentiviral Activation Particles (h) - sc-406744-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr2 Lentiviral Activation Particles (h2) - sc-406744-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr2 siRNA (h) - sc-95444 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ubr2 shRNA Plasmid (h) - sc-95444-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ubr2 shRNA (h) Lentiviral Particles - sc-95444-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UBR2 RNAi - H00023304-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

UBR2 RNAi - H00023304-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU006821 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22415 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22415 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

UBR2 siRNA (Human) - CRH8164 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UBR2 - MBS8214611 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human Ubr2 (NM_015255.2) - SHH439532 from Creative biogene Category siRNA Species Reactivities Human

Human UBR2 siRNA - orb268666 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UBR2 shRNA Plasmid (Human) - CHH8164 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

UBR2 miRNA 3'UTR clone - MiUTR4H-TG09620 from Creative biogene Species Reactivities Human

Search more