| Gene Symbol | WISP1 |
|---|---|
| Entrez Gene | 8840 |
| Alt Symbol | CCN4, WISP1c, WISP1i, WISP1tc |
| Species | Human |
| Gene Type | protein-coding |
| Description | WNT1 inducible signaling pathway protein 1 |
| Other Description | CCN family member 4|CTC-458A3.8|WNT1 induced secreted protein 1|WNT1-inducible-signaling pathway protein 1|Wnt-1 inducible signaling pathway protein 1 |
| Swissprots | Q5JBS8 Q9HCS3 Q5JBS6 O95388 E7EMM5 Q5JBS7 A8KAG6 |
| Accessions | AAF35350 EAW92162 EAW92163 O95388 AB034725 BAB17849 AF100779 AAC96321 AI347990 AK027294 AK293031 BAF85720 AK301508 BAG63017 AK315822 BAF98713 AW291472 AY196486 AAP43924 AY196487 AAP43925 AY196488 AAP43926 BC074840 AAH74840 BC074841 AAH74841 BX476382 DN997366 EF025923 ABK13678 HG501717 KC344835 XM_006716680 XP_006716743 XM_011517358 XP_011515660 XM_011517359 XP_011515661 NM_001204869 NP_001191798 NM_001204870 NP_001191799 NM_003882 NP_003873 NM_080838 NP_543028 NR_037944 |
| Function | Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. {ECO:0000269|PubMed:10716946, ECO:0000269|PubMed:11782444}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma. |
WISP-1 CRISPR/Cas9 KO Plasmid (h) - sc-402559 from Santa Cruz Biotechnology
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WISP-1 HDR Plasmid (h) - sc-402559-HDR from Santa Cruz Biotechnology
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WISP-1 Double Nickase Plasmid (h) - sc-402559-NIC from Santa Cruz Biotechnology
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WISP-1 Double Nickase Plasmid (h2) - sc-402559-NIC-2 from Santa Cruz Biotechnology
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WISP-1 CRISPR Activation Plasmid (h) - sc-402559-ACT from Santa Cruz Biotechnology
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WISP-1 CRISPR Activation Plasmid (h2) - sc-402559-ACT-2 from Santa Cruz Biotechnology
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WISP-1 Lentiviral Activation Particles (h) - sc-402559-LAC from Santa Cruz Biotechnology
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WISP-1 Lentiviral Activation Particles (h2) - sc-402559-LAC-2 from Santa Cruz Biotechnology
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WISP-1 siRNA (h) - sc-39335 from Santa Cruz Biotechnology
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WISP-1 shRNA Plasmid (h) - sc-39335-SH from Santa Cruz Biotechnology
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WISP-1 shRNA (h) Lentiviral Particles - sc-39335-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU081951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22905 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22905 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10087 from Sigma-Aldrich
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WISP1 siRNA (Human) - CRH5836 from Cohesion Biosciences
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WISP1 - MBS8226326 from MyBioSource
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shRNA set against Human WISP1 (NM_003882.3) - SHH447096 from Creative biogene
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shRNA set against Human WISP1(NM_080838.2) - SHL135570 from Creative biogene
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WISP1 shRNA Plasmid (Human) - CHH5836 from Cohesion Biosciences
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WISP1 miRNA 3'UTR clone - MiUTR1H-11271 from Creative biogene
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WISP1 miRNA 3'UTR clone - MiUTR3H-05930 from Creative biogene
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