WISP1

Gene Symbol WISP1
Entrez Gene 8840
Alt Symbol CCN4, WISP1c, WISP1i, WISP1tc
Species Human
Gene Type protein-coding
Description WNT1 inducible signaling pathway protein 1
Other Description CCN family member 4|CTC-458A3.8|WNT1 induced secreted protein 1|WNT1-inducible-signaling pathway protein 1|Wnt-1 inducible signaling pathway protein 1
Swissprots Q5JBS8 Q9HCS3 Q5JBS6 O95388 E7EMM5 Q5JBS7 A8KAG6
Accessions AAF35350 EAW92162 EAW92163 O95388 AB034725 BAB17849 AF100779 AAC96321 AI347990 AK027294 AK293031 BAF85720 AK301508 BAG63017 AK315822 BAF98713 AW291472 AY196486 AAP43924 AY196487 AAP43925 AY196488 AAP43926 BC074840 AAH74840 BC074841 AAH74841 BX476382 DN997366 EF025923 ABK13678 HG501717 KC344835 XM_006716680 XP_006716743 XM_011517358 XP_011515660 XM_011517359 XP_011515661 NM_001204869 NP_001191798 NM_001204870 NP_001191799 NM_003882 NP_003873 NM_080838 NP_543028 NR_037944
Function Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. {ECO:0000269|PubMed:10716946, ECO:0000269|PubMed:11782444}.
Subcellular Location Secreted.
Tissue Specificity Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma.

WISP-1 (A-9) - sc-133126 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
WISP-1 (A-9): sc-133126. Western blot analysis of human recombinant WISP-1 fusion protein.

WISP-1 (C-2) - sc-133198 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
WISP-1 (C-2): sc-133198. Western blot analysis of human recombinant WISP-1.

WISP-1 (N-19) - sc-8864 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
WISP-1 (N-19): sc-8864. Western blot analysis of WISP-1 expression in JAR whole cell lysate.

WISP-1 (H-55) - sc-25441 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
WISP-1 (H-55): sc-25441. Western blot analysis of human recombinant WISP-1.

Anti-WISP1 antibody - ab10737 from Abcam

Host Rabbit
Clonality Polyclonal
Image courtesy of Human Protein Atlasab10737 staining WISP1 in human bone marrow, showing staining with haemapoietic tissue and not apidose tissue. Paraffin embedded human bome marrow tissue was incubated with ab10737 (1/75 dilution) for 30 mins at room temperature. Antigen retrieval was performed by heat induction in citrate buffer pH 6. ab10737 was tested in a tissue microarray (TMA) containing a wide range of normal and cancer tissues as well as a cell microarray consisting of a range of commonly used, well characterised human cell lines. Further results for this antibody can be found at www.proteinatlas.org

Anti-WISP1 antibody - ab155654 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-WISP1 antibody (ab155654) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-WISP1 antibody - ab65943 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-WISP1 antibody (ab65943) at 0.1 µg/ml + HEK293 cell lysates at 35 µg

Anti-WISP1 antibody - ab60114 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab60114 (1/50-1/100) staining human WISP1 in human cancer tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. HC = hepatocarcinoma.

Anti-WISP1 antibody [MM0603-7H14] - ab89936 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0603-7H14

Anti-WISP1 antibody - C-terminal - ab178547 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded rat kidney tissue labeling WISP1 with ab178547 at 1 µg/ml.

Anti-CCN4 / WISP1 Antibody (aa354-367) - LS-C313208 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
CCN4 / WISP1 antibody. IHC(P): Human Placenta Tissue.

Anti-CCN4 / WISP1 Antibody - LS-C144272 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-CCN4 / WISP1 Antibody (Internal, APC) - LS-C246381 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCN4 / WISP1 Antibody (Internal, AP) - LS-C246382 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCN4 / WISP1 Antibody (Internal, Biotin) - LS-C246383 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCN4 / WISP1 Antibody (Internal, FITC) - LS-C246384 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCN4 / WISP1 Antibody (Internal, PE) - LS-C246385 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCN4 / WISP1 Antibody (Internal, Azide-free, HRP) - LS-C247973 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCN4 / WISP1 Antibody (aa216-347, Biotin) - LS-C298579 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCN4 / WISP1 Antibody (aa213-350, Biotin) - LS-C298581 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCN4 / WISP1 Antibody (aa216-347, FITC) - LS-C301883 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCN4 / WISP1 Antibody (aa213-350, FITC) - LS-C301885 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCN4 / WISP1 Antibody (Internal) - LS-C330734 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCN4 / WISP1 Antibody (aa216-347) - LS-C297019 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CCN4 / WISP1.

Anti-CCN4 / WISP1 Antibody (aa357-367) - LS-C55692 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of HEK293 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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