POLR3E

Gene Symbol POLR3E
Entrez Gene 55718
Alt Symbol RPC5, SIN
Species Human
Gene Type protein-coding
Description polymerase (RNA) III (DNA directed) polypeptide E (80kD)
Other Description DNA-directed RNA polymerase III 80 kDa polypeptide|DNA-directed RNA polymerase III subunit RPC5|RNA polymerase III 80 kDa subunit RPC5|RNA polymerase III subunit C5
Swissprots B4DL24 Q9P276 Q9H907 Q9H8W8 H3BT11 Q9BWF7 Q9NVU0 B4DUP6
Accessions CAE89351 EAW50605 EAW50606 EAW50607 EAW50608 Q9NVU0 AA282721 AB040885 BAA95976 AK001371 BAA91655 AK023160 BAB14437 AK023231 BAB14481 AK026645 AK130661 AK222671 AK222789 BAD96509 AK293300 BAG56821 AK296813 BAG59386 AK300735 BAG62408 AL048627 AW205673 AY092085 AAM18215 BC000285 AAH00285 DB047155 XM_006721063 XP_006721126 XM_011545892 XP_011544194 XM_011545893 XP_011544195 NM_001258033 NP_001244962 NM_001258034 NP_001244963 NM_001258035 NP_001244964 NM_001258036 NP_001244965 NM_018119 NP_060589 NR_047581
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
Subcellular Location Nucleus.
Top Pathways Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

POLR3E (B-11) - sc-365703 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
POLR3E (B-11): sc-365703. Western blot analysis of POLR3E expression in COLO 320DM (A) and Ramos (B) whole cell lysates.

POLR3E (E-15) - sc-107950 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

POLR3E (N-14) - sc-107951 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
POLR3E (N-14): sc-107951. Western blot analysis of POLR3E expression in non-transfected: sc-117752 (A) and mouse POLR3E transfected: sc-127365 (B) 293T whole cell lysates.

Anti-POLR3E antibody - ab134560 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-POLR3E antibody (ab134560) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-POLR3E antibody - ab127893 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-POLR3E antibody (ab127893) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

Anti-POLR3E antibody - ab134570 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of POLR3E by Western Blot of Immunprecipitate. Immunoprecipitation of HeLa whole cell lysate using ab134570 (lane 1) at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Immunoblot analysis of POLR3E utilised an antibody to a downstream epitope at 1µg/ml. The lysate in lane 2 is precipitated with an IgG control antibody. Detection: Chemiluminescence with exposure time of 10 seconds.

Anti-POLR3E antibody [2791C3a] - ab84863 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2791C3a
Anti-POLR3E antibody [2791C3a] (ab84863) + Immunogen (Recombinant Human POLR3E fragment)

Anti-POLR3E / SIN Antibody - LS-C126144 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-POLR3E / SIN Antibody (clone 2791C3a) - LS-C184742 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2791C3a

Anti-POLR3E / SIN Antibody (aa175-225) - LS-C290364 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3E / SIN Antibody (aa475-525) - LS-C290366 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3E / SIN Antibody (aa191-240) - LS-C119920 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-POLR3E / SIN Antibody (clone 2791C3a) - LS-C342864 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2791C3a
Western blot analysis of immunized recombinant protein, using anti-POLR3E monoclonal antibody.

Anti-POLR3E / SIN Antibody - LS-C155686 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of paraformaldehyde-fixed A431, using POLR3E antibody at 1:500 dilution.

POLR3E Antibody - NBP1-84621 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

POLR3E Antibody - NBP2-19887 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: POLR3E Antibody [NBP2-19887] - Sample (30 ug of whole cell lysate) A: Jurakt 7. 5% SDS PAGE gel, diluted at 1:1000.

POLR3E Antibody - NBP2-19886 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RPC5 (center) antibody produced in rabbit - SAB1300607 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPC5 antibody produced in rabbit - SAB4502346 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RPC5: <B>Cat. No. SAB4502346</B>: Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Anti-RPC5 antibody. Cells on the left were treated with the Anti-RPC5 antibody. Cells on the right (negative control) were treated with both Anti-RPC5 antibody and the synthesized immunogen peptide.

Anti-POLR3E antibody produced in rabbit - HPA041477 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-POLR3E: <B>Cat. No. HPA041477</B>: Immunohistochemical staining of human stomach, lower shows strong nuclear positivity in glandular cells.

Anti-RPC5 (N-term) antibody produced in rabbit - SAB1300240 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

POLR3E antibody - 10R-1711 from Fitzgerald

Prices $190.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2791C3a

POLR3E Antibody - abx036024 from Abbexa

Host Rabbit
Clonality Polyclonal

RPC5 Antibody - abx119440 from Abbexa

Host Rabbit
Clonality Polyclonal

Mouse Anti-Human POLR3E - JI-04-00765 from RayBiotech

Host Mouse
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