POLR3E

Gene Symbol POLR3E
Entrez Gene 55718
Alt Symbol RPC5, SIN
Species Human
Gene Type protein-coding
Description polymerase (RNA) III (DNA directed) polypeptide E (80kD)
Other Description DNA-directed RNA polymerase III 80 kDa polypeptide|DNA-directed RNA polymerase III subunit RPC5|RNA polymerase III 80 kDa subunit RPC5|RNA polymerase III subunit C5
Swissprots B4DL24 Q9P276 Q9H907 Q9H8W8 H3BT11 Q9BWF7 Q9NVU0 B4DUP6
Accessions CAE89351 EAW50605 EAW50606 EAW50607 EAW50608 Q9NVU0 AA282721 AB040885 BAA95976 AK001371 BAA91655 AK023160 BAB14437 AK023231 BAB14481 AK026645 AK130661 AK222671 AK222789 BAD96509 AK293300 BAG56821 AK296813 BAG59386 AK300735 BAG62408 AL048627 AW205673 AY092085 AAM18215 BC000285 AAH00285 DB047155 XM_006721063 XP_006721126 XM_011545892 XP_011544194 XM_011545893 XP_011544195 NM_001258033 NP_001244962 NM_001258034 NP_001244963 NM_001258035 NP_001244964 NM_001258036 NP_001244965 NM_018119 NP_060589 NR_047581
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
Subcellular Location Nucleus.
Top Pathways Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

POLR3E CRISPR/Cas9 KO Plasmid (h) - sc-410024 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3E HDR Plasmid (h) - sc-410024-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3E Double Nickase Plasmid (h) - sc-410024-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3E Double Nickase Plasmid (h2) - sc-410024-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3E CRISPR Activation Plasmid (h) - sc-410024-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3E CRISPR Activation Plasmid (h2) - sc-410024-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3E Lentiviral Activation Particles (h) - sc-410024-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3E Lentiviral Activation Particles (h2) - sc-410024-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3E siRNA (h) - sc-93337 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

POLR3E shRNA Plasmid (h) - sc-93337-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

POLR3E shRNA (h) Lentiviral Particles - sc-93337-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU079021 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17130 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17130 from Sigma-Aldrich

Category ZFN Kit
Prices $4,120.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02400 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02400

POLR3E siRNA (Human) - CRJ0859 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human POLR3E (NM_018119.3) - SHH379576 from Creative biogene

Category siRNA
Species Reactivities Human

Human POLR3E siRNA - orb271360 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

POLR3E shRNA Plasmid (Human) - CHJ0859 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

POLR3E miRNA 3'UTR clone - MiUTR3H-15744 from Creative biogene

Species Reactivities Human
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