| Gene Symbol |
POLR3E
|
| Entrez Gene |
55718
|
| Alt Symbol |
RPC5, SIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
|
| Other Description |
DNA-directed RNA polymerase III 80 kDa polypeptide|DNA-directed RNA polymerase III subunit RPC5|RNA polymerase III 80 kDa subunit RPC5|RNA polymerase III subunit C5
|
| Swissprots |
B4DL24 Q9P276 Q9H907 Q9H8W8 H3BT11 Q9BWF7 Q9NVU0 B4DUP6
|
| Accessions |
CAE89351 EAW50605 EAW50606 EAW50607 EAW50608 Q9NVU0 AA282721 AB040885 BAA95976 AK001371 BAA91655 AK023160 BAB14437 AK023231 BAB14481 AK026645 AK130661 AK222671 AK222789 BAD96509 AK293300 BAG56821 AK296813 BAG59386 AK300735 BAG62408 AL048627 AW205673 AY092085 AAM18215 BC000285 AAH00285 DB047155 XM_006721063 XP_006721126 XM_011545892 XP_011544194 XM_011545893 XP_011544195 NM_001258033 NP_001244962 NM_001258034 NP_001244963 NM_001258035 NP_001244964 NM_001258036 NP_001244965 NM_018119 NP_060589 NR_047581
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism
|