POLR3E

Gene Symbol	POLR3E
Entrez Gene	55718
Alt Symbol	RPC5, SIN
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) III (DNA directed) polypeptide E (80kD)
Other Description	DNA-directed RNA polymerase III 80 kDa polypeptide|DNA-directed RNA polymerase III subunit RPC5|RNA polymerase III 80 kDa subunit RPC5|RNA polymerase III subunit C5
Swissprots	B4DL24 Q9P276 Q9H907 Q9H8W8 H3BT11 Q9BWF7 Q9NVU0 B4DUP6
Accessions	CAE89351 EAW50605 EAW50606 EAW50607 EAW50608 Q9NVU0 AA282721 AB040885 BAA95976 AK001371 BAA91655 AK023160 BAB14437 AK023231 BAB14481 AK026645 AK130661 AK222671 AK222789 BAD96509 AK293300 BAG56821 AK296813 BAG59386 AK300735 BAG62408 AL048627 AW205673 AY092085 AAM18215 BC000285 AAH00285 DB047155 XM_006721063 XP_006721126 XM_011545892 XP_011544194 XM_011545893 XP_011544195 NM_001258033 NP_001244962 NM_001258034 NP_001244963 NM_001258035 NP_001244964 NM_001258036 NP_001244965 NM_018119 NP_060589 NR_047581
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus.
Top Pathways	Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human POLR3E full length protein - ab163189 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human POLR3E Protein - H00055718-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

POLR3E / RPC5 - H00055718-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

POLR3E / RPC5 - H00055718-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

POLR3E fusion protein - ag7231 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

POLR3E fusion protein - ag7098 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DNA-directed RNA polymerase III subunit RPC5(POLR3E) - CSB-YP868333HU CSB-EP868333HU CSB-BP868333HU CSB-MP868333HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

POLR3E / RPC5 - TP318588 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

POLR3E Blocking Peptide - abx061294 from Abbexa Category Peptide Species Human, Monkey

POLR3E Recombinant Protein Antigen - NBP1-84621PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RPC5-Antibody-Center-Blocking-Peptide - BP1956c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RPC5-Antibody-N-term-Blocking-Peptide - BP1956a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

POLR3E Peptide, Human - M34GP12108H from Creative Peptides Category Peptide Source Synthetic. Species Human

POLR3E Blocking Peptide - CBP5207 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

DNA-directed RNA polymerase III subunit RPC5 (POLR3E), Recombinant Protein - MBS1337090 from MyBioSource Category Protein Prices $1,515.00, $1,515.00, $1,745.00, $1,745.00, $2,595.00, $2,595.00, $3,040.00, $3,040.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

POLR3E Recombinant Protein Antigen - NBP2-58956PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

POLR3E peptide - orb319353 from Biorbyt Category Peptide

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