| Gene Symbol |
SPRY4
|
| Entrez Gene |
81848
|
| Alt Symbol |
HH17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sprouty homolog 4 (Drosophila)
|
| Other Description |
protein sprouty homolog 4
|
| Swissprots |
A4FVB2 Q9C004 A4FVB3 Q6QIX2 Q9C003
|
| Accessions |
AAS46253 Q9C004 AF227516 AAK00652 AF251060 AAK34950 AK096464 BAC04798 AK226147 BC125095 AAI25096 BC125096 AAI25097 BP387943 DA183391 T32786 XM_005268519 XP_005268576 XM_011537685 XP_011535987 NM_001127496 NP_001120968 NM_001293289 NP_001280218 NM_001293290 NP_001280219 NM_030964 NP_112226
|
| Function |
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1. {ECO:0000269|PubMed:12717443}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12027893}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
|
| Top Pathways |
Jak-STAT signaling pathway
|