SPRY4

Gene Symbol SPRY4
Entrez Gene 81848
Alt Symbol HH17
Species Human
Gene Type protein-coding
Description sprouty homolog 4 (Drosophila)
Other Description protein sprouty homolog 4
Swissprots A4FVB2 Q9C004 A4FVB3 Q6QIX2 Q9C003
Accessions AAS46253 Q9C004 AF227516 AAK00652 AF251060 AAK34950 AK096464 BAC04798 AK226147 BC125095 AAI25096 BC125096 AAI25097 BP387943 DA183391 T32786 XM_005268519 XP_005268576 XM_011537685 XP_011535987 NM_001127496 NP_001120968 NM_001293289 NP_001280218 NM_001293290 NP_001280219 NM_030964 NP_112226
Function Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1. {ECO:0000269|PubMed:12717443}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12027893}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Top Pathways Jak-STAT signaling pathway

Sprouty 4 (H-100) - sc-30051 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Sprouty 4 (L-17) - sc-18607 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sprouty 4 (L-17): sc-18607. Immunofluorescence staining of methanol-fixed Hep G2 cells showing cytoplasmic localization.

Sprouty 4 (V-15) - sc-18609 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sprouty 4 (V-15): sc-18609. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

Anti-Sprouty 4 (phospho Y75) antibody - ab103114 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab103114, at 1/50 dilution, staining Sprouty 4 in formalin-fixed, paraffin-embedded Human brain tissue by Immunohistochemistry followed by peroxidase conjugation of the secondary antibody and DAB detection.

Anti-Sprouty 4 antibody - ab115557 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115557, at 2.5µg/ml, staining Sprouty 4 in Formalin-fixed, Paraffin-embedded Human heart tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Sprouty 4 antibody [EPR12127] - ab176337 from Abcam

Prices $99.00, $385.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12127
Western blot analysis on immunoprecipitation pellet from MCF-7 cells lysate (lane 1) or 1XPBS (negative control, lane 2) using ab176337 at 1/10 dilution and HRP-conjugated anti-rabbit IgG preferentially detecting the non-reduced form of rabbit IgG.

Anti-Sprouty 4 antibody - C-terminal - ab82298 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Sprouty 4 antibody - C-terminal (ab82298) at 1/50 dilution + Sk-Br-3 cell line lysate at 35 µg

Anti-Sprouty 4 / SPRY4 Antibody (aa283-299) - LS-C89244 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (N-Terminus) - LS-C144695 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (N-Terminus) - LS-C153564 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (aa57-86, AP) - LS-C224137 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (aa57-86, APC) - LS-C224138 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (aa57-86, Biotin) - LS-C224139 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (aa57-86, FITC) - LS-C224140 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (phospho-Tyr75) - LS-C97105 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot of anti-Phospho-SPRY4-pY75 Antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Anti-Sprouty 4 / SPRY4 Antibody (aa57-86, Azide-free, HRP) - LS-C224141 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (aa57-86, PE) - LS-C224143 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (phospho-Tyr75, AP) - LS-C226397 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (phospho-Tyr75, Biotin) - LS-C226399 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (phospho-Tyr75, APC) - LS-C226398 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (phospho-Tyr75, FITC) - LS-C226400 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (phospho-Tyr75, Azide-free, HRP) - LS-C226401 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (phospho-Tyr75, PE) - LS-C226402 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (C-Terminus, AP) - LS-C226403 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Sprouty 4 / SPRY4 Antibody (C-Terminus) - LS-C116397 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SPRY4 antibody LS-C116397 Western blot of HeLa lysate.
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