PVRL1

Gene Symbol	PVRL1
Entrez Gene	5818
Alt Symbol	CD111, CLPED1, ED4, HIgR, HV1S, HVEC, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12, nectin-1
Species	Human
Gene Type	protein-coding
Description	poliovirus receptor-related 1 (herpesvirus entry mediator C)
Other Description	ectodermal dysplasia 4 (Margarita Island type)|herpes simplex virus type 1 sensitivity|herpes virus entry mediator C|herpesvirus Ig-like receptor|nectin 1|nectin-1|poliovirus receptor-like 1|poliovirus receptor-related protein 1
Swissprots	O75465 Q15223 Q9HBW2 Q9HBE6 Q2M3D3
Accessions	AAG16648 AAG16649 AAL47715 AAL47716 AAR88250 AAR88251 AAR88252 EAW67492 EAW67493 EAW67494 Q15223 AF060231 AAC23798 AF110314 AAD04944 AI819997 AK056455 AK091231 AK095375 AY029539 AAK33124 BC007379 BC021976 BC044230 BC064140 BC086309 BC104948 AAI04949 BC113471 AAI13472 BQ188335 HQ258297 ADR83051 X76400 CAA53980 NM_002855 NP_002846 NM_203285 NP_976030 NM_203286 NP_976031 NM_032767
Function	Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus. Has some neurite outgrowth-promoting activity. {ECO:0000269|PubMed:21980294, ECO:0000269|PubMed:7721102}.
Subcellular Location	Isoform Gamma: Secreted.
Top Pathways	Adherens junction, Cell adhesion molecules (CAMs), Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PVRL1 full length protein - ab132719 from Abcam Category Protein Source Wheat germ Species Human

Human PVRL1 peptide - ab73475 from Abcam Category Peptide

Human PVRL1 protein fragment - ab151682 from Abcam Category Protein Source HEK 293 cells Species Human

Human PVRL1 protein fragment - ab159289 from Abcam Category Protein Source Wheat germ Species Human

Nectin-1 / PVRL1 Antibody Blocking Peptide - LS-E22425 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Nectin-1/PVRL1 Partial Recombinant Protein - H00005818-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Nectin-1/PVRL1 Recombinant Protein - H00005818-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Nectin-1/PVRL1 Peptide - P1864 from Novus Biologicals Category Peptide Species Human

Nectin-1/PVRL1 Recombinant Protein - H00005818-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

PVRL1-Antibody-C-term-Blocking-Peptide - BP14522b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PVRL1-Antibody-C-term-Blocking-Peptide - BP6259a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Nectin-1, CF - 2880-N1-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln31-Thr334 with a C-terminal 6-His tag

Human CD111 protein - orb83816 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human PVRL1 protein - orb49597 from Biorbyt Category Protein Prices $272.00, $366.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293

PVRL1 Blocking Peptide - 33R-7637 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CD111 / Nectin 1 - H00005818-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD111 / Nectin 1 - H00005818-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD111 / Nectin 1 - H00005818-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD111 / Nectin 1 - H00005818-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD111 / Nectin 1 - H00005818-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD111 / Nectin 1 - HA266-050 from Acris Antibodies Category Protein Prices $360.00 Sizes 50 µg Source Sf9-Baculovirus Species Human

Poliovirus Receptor-Related Protein 1, PVRL1, Human, Recombinant - 19-C492 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source HEK293 Species Human

Nectin 1 Recombinant Protein - 96-642 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

PVRL1 fusion protein - ag20074 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PVRL1 fusion protein - ag20373 from Proteintech Group Category Protein Source E. coli-derived, PET30a Species Human

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