PVRL1
| Gene Symbol | PVRL1 |
|---|---|
| Entrez Gene | 5818 |
| Alt Symbol | CD111, CLPED1, ED4, HIgR, HV1S, HVEC, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12, nectin-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | poliovirus receptor-related 1 (herpesvirus entry mediator C) |
| Other Description | ectodermal dysplasia 4 (Margarita Island type)|herpes simplex virus type 1 sensitivity|herpes virus entry mediator C|herpesvirus Ig-like receptor|nectin 1|nectin-1|poliovirus receptor-like 1|poliovirus receptor-related protein 1 |
| Swissprots | O75465 Q15223 Q9HBW2 Q9HBE6 Q2M3D3 |
| Accessions | AAG16648 AAG16649 AAL47715 AAL47716 AAR88250 AAR88251 AAR88252 EAW67492 EAW67493 EAW67494 Q15223 AF060231 AAC23798 AF110314 AAD04944 AI819997 AK056455 AK091231 AK095375 AY029539 AAK33124 BC007379 BC021976 BC044230 BC064140 BC086309 BC104948 AAI04949 BC113471 AAI13472 BQ188335 HQ258297 ADR83051 X76400 CAA53980 NM_002855 NP_002846 NM_203285 NP_976030 NM_203286 NP_976031 NM_032767 |
| Function | Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus. Has some neurite outgrowth-promoting activity. {ECO:0000269|PubMed:21980294, ECO:0000269|PubMed:7721102}. |
| Subcellular Location | Isoform Gamma: Secreted. |
| Top Pathways | Adherens junction, Cell adhesion molecules (CAMs), Herpes simplex infection |
Nectin 1 CRISPR/Cas9 KO Plasmid (h) - sc-401328 from Santa Cruz Biotechnology
|
||||||||
Nectin 1 HDR Plasmid (h) - sc-401328-HDR from Santa Cruz Biotechnology
|
||||||||
Nectin 1 Double Nickase Plasmid (h) - sc-401328-NIC from Santa Cruz Biotechnology
|
||||||||
Nectin 1 Double Nickase Plasmid (h2) - sc-401328-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Nectin 1 CRISPR Activation Plasmid (h) - sc-401328-ACT from Santa Cruz Biotechnology
|
||||||||
Nectin 1 CRISPR Activation Plasmid (h2) - sc-401328-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Nectin 1 Lentiviral Activation Particles (h) - sc-401328-LAC from Santa Cruz Biotechnology
|
||||||||
Nectin 1 Lentiviral Activation Particles (h2) - sc-401328-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Nectin 1 siRNA (h) - sc-36022 from Santa Cruz Biotechnology
|
||||||||
Nectin 1 shRNA Plasmid (h) - sc-36022-SH from Santa Cruz Biotechnology
|
||||||||
Nectin 1 shRNA (h) Lentiviral Particles - sc-36022-V from Santa Cruz Biotechnology
|
||||||||
Nectin-1/PVRL1 RNAi - H00005818-R02 from Novus Biologicals
|
||||||||
Nectin-1/PVRL1 RNAi - H00005818-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU151791 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17749 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17749 from Sigma-Aldrich
|
||||||||
PVRL1 siRNA (Human) - CRH3933 from Cohesion Biosciences
|
||||||||
Nectin-1/PVRL1 RNAi - H00005818-R03 from Novus Biologicals
|
||||||||
shRNA set against Human PVRL1 (NM_002855.4) - SHH387180 from Creative biogene
|
||||||||
shRNA set against Human PVRL1(NM_203286.1) - SHR155202 from Creative biogene
|
||||||||
shRNA set against Human PVRL1(NM_002855.4) - SHR155220 from Creative biogene
|
||||||||
shRNA set against Human PVRL1(NM_203285.1) - SHR155238 from Creative biogene
|
||||||||
Human PVRL1 siRNA - orb264435 from Biorbyt
|
||||||||
PVRL1 shRNA Plasmid (Human) - CHH3933 from Cohesion Biosciences
|
||||||||
PVRL1 miRNA 3'UTR clone - MiUTR1H-08502 from Creative biogene
|