| Gene Symbol |
CLK4
|
| Entrez Gene |
57396
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CDC-like kinase 4
|
| Other Description |
dual specificity protein kinase CLK4|protein serine threonine kinase Clk4
|
| Swissprots |
Q9HAZ1
|
| Accessions |
EAW53831 EAW53832 Q9HAZ1 AF294429 AAG10074 AK294921 BAH11925 AK304614 BAH14226 AK308578 AK308674 AK308879 AK309215 AK310427 AK311485 BC015942 BC034633 AAH34633 BC046211 BC063116 BC065732 AAH65732 BC136261 AAI36262 BC143538 BC143547 AAI43548 BC151233 BX647323 CB127989 CR749504 CAH18325 XM_005265947 XP_005266004 XM_005265948 XP_005266005 XM_005265949 XP_005266006 XM_006714895 XP_006714958 XM_006714896 XP_006714959 XM_011534601 XP_011532903 XM_011534602 XP_011532904 XM_011534603 XP_011532905 XR_427807 NM_020666 NP_065717
|
| Function |
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed in liver, kidney, heart, muscle, brain and endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}.
|