CLK4

Gene Symbol CLK4
Entrez Gene 57396
Alt Symbol -
Species Human
Gene Type protein-coding
Description CDC-like kinase 4
Other Description dual specificity protein kinase CLK4|protein serine threonine kinase Clk4
Swissprots Q9HAZ1
Accessions EAW53831 EAW53832 Q9HAZ1 AF294429 AAG10074 AK294921 BAH11925 AK304614 BAH14226 AK308578 AK308674 AK308879 AK309215 AK310427 AK311485 BC015942 BC034633 AAH34633 BC046211 BC063116 BC065732 AAH65732 BC136261 AAI36262 BC143538 BC143547 AAI43548 BC151233 BX647323 CB127989 CR749504 CAH18325 XM_005265947 XP_005266004 XM_005265948 XP_005266005 XM_005265949 XP_005266006 XM_006714895 XP_006714958 XM_006714896 XP_006714959 XM_011534601 XP_011532903 XM_011534602 XP_011532904 XM_011534603 XP_011532905 XR_427807 NM_020666 NP_065717
Function Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}.
Subcellular Location Nucleus {ECO:0000250}.
Tissue Specificity Expressed in liver, kidney, heart, muscle, brain and endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}.

Anti-CLK4 antibody - ab104321 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CLK4 antibody (ab104321) at 1 µg/ml + Human fetal brain lysate at 10 µg

Anti-CLK4 antibody - ab67936 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-CLK4 antibody (ab67936) at 1/500 dilutionLane 1 : CLK4 transfected 293T cell lysateLane 2 : non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-CLK4 antibody - ab130831 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CLK4 antibody (ab130831) at 0.25 µg/ml + Mouse Pancreas lysates at 10 µg

Anti-CLK4 Antibody (aa101-150) IHC-plus™ - LS-B10003 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CLK4 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CLK4 Antibody (aa48-77, AP) - LS-C233969 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLK4 Antibody (aa48-77, APC) - LS-C233970 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLK4 Antibody (aa48-77, Biotin) - LS-C233972 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLK4 Antibody (aa48-77, FITC) - LS-C233973 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLK4 Antibody (aa48-77, PE) - LS-C233975 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLK4 Antibody (aa51-100) - LS-C151178 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CLK4 antibody Western Blot of Mouse Pancreas.

Anti-CLK4 Antibody (aa48-77, Azide-free, HRP) - LS-C249702 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLK4 Antibody (aa83-132) - LS-C291812 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLK4 Antibody - LS-C306995 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CLK4 Antibody (aa107-156) - LS-C115957 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CLK4 antibody LS-C115957 Western blot of Fetal Brain lysate.

Anti-CLK4 Antibody (aa48-77) - LS-C320451 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLK4 Antibody (aa48-77) - LS-C164349 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Clk4 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The Clk4 antibody detected the Clk4 protein (arrow).

CLK4 Antibody - NBP1-55732 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CLK4 Antibody [NBP1-55732] - Analysis of extracts from HT-29 cells, using CLK4 Antibody. The lane on the right is treated with the synthesized peptide.

CLK4 Antibody - H00057396-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: CLK4 Antibody [H00057396-B01P] - Analysis of CLK4 expression in A-431.

Anti-CLK4 antibody produced in mouse - SAB1407785 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CLK4: <B>Cat. No. SAB1407785</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~52.9 kDa using CLK4 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-CLK4 antibody produced in rabbit - HPA043746 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CLK4: <B>Cat. No. HPA043746</B>: Immunohistochemical staining of human bronchus shows strong nuclear positivity in respiratory epithelial cells.

Anti-CLK4 antibody produced in rabbit - SAB4502487 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CLK4: <B>Cat. No. SAB4502487</B>: Immunoblotting analysis of extracts from HT-29 cells, using Anti-CLK4 antibody. The lane on the left was treated with the Anti-CLK4 antibody. The lane on the right (negative control) was treated with both Anti-CLK4 antibody and the synthesized immunogen peptide.

Anti-CLK4 (61-75) antibody produced in rabbit - C2744 from Sigma-Aldrich

Prices $342.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-CLK4 (61-75) (RB): <B>Cat. No. C2744</B>: Immunofluorescence of HUVEC cells using CLK4 (61-75) (RB), <B>Cat. No. C2744</B> (red) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used.<BR/>Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-CLK4 antibody produced in rabbit - HPA048118 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CLK4: <B>Cat. No. HPA048118</B>: Immunohistochemical staining of human liver shows moderate cytoplasmic, membranous and nuclear positivity in hepatocytes.

CLK4 antibody - N-terminal region (ARP30645_P050) - ARP30645_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CLK4 antibody, N-term - GTX44602 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-CLK4 antibody, N-term used in Western blot. GTX44602
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