HDAC5

Gene Symbol HDAC5
Entrez Gene 10014
Alt Symbol HD5, NY-CO-9
Species Human
Gene Type protein-coding
Description histone deacetylase 5
Other Description antigen NY-CO-9
Swissprots C9JFV9 Q9UQL6 Q96DY4 O60340 O60528
Accessions DAA00017 EAW51633 EAW51634 Q9UQL6 AB011172 BAA25526 AB177853 BAD66831 AF039691 AAC18040 AF132608 AAD29047 AK027734 BAB55329 AK075095 AK093150 AK294760 BAG57895 BC011260 BC013140 AAH13140 BC038423 BC041914 BC051824 AAH51824 BM564861 BM998071 CN290533 XM_005256904 XP_005256961 XM_005256905 XP_005256962 XM_005256906 XP_005256963 XM_005256907 XP_005256964 XM_011524149 XP_011522451 XM_011524150 XP_011522452 XM_011524151 XP_011522453 XR_934338 NM_001015053 NP_001015053 NM_005474 NP_005465 NM_139205
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:24413532}.
Subcellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
Tissue Specificity Ubiquitous.
Top Pathways Viral carcinogenesis, Epstein-Barr virus infection, Alcoholism

Histone Deacetylase 5 (HDAC5) Antibody - 2082 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

HDAC5 (B-11) - sc-133106 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HDAC5 (B-11): sc-133106. Western blot analysis of HDAC5 expression in IMR-32 (A) and KNRK (B) whole cell lysates.

HDAC5 (C-11) - sc-133225 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HDAC5 (C-11): sc-133225. Western blot analysis of HDAC5 expression in NIH/3T3 (A), KNRK (B), IMR-32 (C) and Jurkat (D) nuclear extracts and KNRK (E) and COLO 320DM (F) whole cell lysates.

HDAC5 (G-18) - sc-5250 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HDAC5 (G-18): sc-5250. Western blot analysis of HDAC5 expression in KNRK nuclear extract.

HDAC5 (H-74) - sc-11419 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HDAC5 (H-74): sc-11419. Immunofluorescence staining of methanol-fixed KNRK cells showing nuclear localization.

HDAC5 (P-16) - sc-5252 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HDAC5 (P-16): sc-5252. Western blot analysis of HDAC5 expression in Jurkat nuclear extract.

p-HDAC5 (Ser 498) - sc-101692 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of phosphorylated HDAC5 expression in NIH/3T3 whole cell lysates. Blots were probed with p-HDAC5 (Ser 498): sc-101692 preincubated with cognate phosphorylated peptide (A) and p-HDAC5 (Ser 498): sc-101692 (B).

Anti-HDAC4 + 5 + 9 antibody - ab131524 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC4 + 5 + 9 antibody (ab131524) at 1/500 dilutionLane 1 : 293 cell lysateLane 2 : HeLa cell lysate

Anti-HDAC5 (phospho S259) antibody - ab192339 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC5 (phospho S259) antibody (ab192339) at 1/500 dilutionLane 1 : HepG2 whole cell lysate with antigen-specific peptideLane 2 : HepG2 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-HDAC5 (phospho S498) antibody - ab47283 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC5 (phospho S498) antibody (ab47283) at 1/500 dilutionLane 1 : Extracts from NIH/ 3T3 cellsLane 2 : Extracts from NIH/ 3T3 cells; ab47283 preincubated with immunising peptide (blocking)

Anti-HDAC5 antibody - ab1439 from Abcam

Prices $392.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC5 antibody (ab1439) at 1/1000 dilutionLane 1 : Rat hippocampus cell lysateLane 2 : Rat hippocampus cell lysateLysates/proteins at 15 µg per lane.SecondaryPolyclonal anti-rabbit IgG HRP conjugate at 1/2000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-HDAC5 antibody - ab55403 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab55403 (1/50 dilution) in the presence and absence of the immunizing peptide.

Anti-HDAC5 antibody - ab47519 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC5 antibody (ab47519) at 1/500 dilutionLane 1 : Extracts from NIH/3T3 cells untreatedLane 2 : Extracts from NIH/3T3 cells treated with synthesized peptide

Anti-HDAC5 antibody - ab11969 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HDAC5 detection by Western blot. The detection of HDAC5 in 293 (lane 1), Jurkat (lane 2) and NIH/3T3 (lane 3) cell extract using the HDAC5 antibody at a 2 µg/ml dilution.

Anti-HDAC5 antibody - ab53706 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab53706 at 1/50 dilution stainng HDAC5 in human breast carcinoma by Immunohistochemistry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.

Anti-HDAC5 antibody - ab56929 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-HDAC5 antibody [HDAC5-35] - ab50001 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone HDAC5-35
Lane 1 : Anti-HDAC5 antibody [HDAC5-35] (ab50001) at 2 µg/mlLane 2 : no primary antibodyLane 1 : 3T3 cell extract (mouse fibroblasts)Lane 2 : 3T3 cell extract (mouse fibroblasts)SecondaryGoat Anti-Mouse, Peroxidase conjugate

Anti-HDAC5 Antibody (aa536-545) - LS-C7360 from LifeSpan Bioscience

Prices $560.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-HDAC5 Antibody - LS-C7361 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HDAC5 Antibody (N-Terminus) - LS-C7413 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HDAC5 Antibody - LS-C123689 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HDAC5 Antibody (phospho-Ser498) - LS-C123694 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HDAC5 Antibody (aa330-429, clone 10D53, Azide-free) - LS-C183673 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10D53

Anti-HDAC5 Antibody (phospho-Ser498) - LS-C190888 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HDAC5 Antibody (aa572-587) - LS-C692 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of HDAC5 in 293 (lane 1), Jurkat (lane 2) and NIH-3T3 (lane 3) cell lysate with antibody.
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