| Gene Symbol |
HDAC5
|
| Entrez Gene |
10014
|
| Alt Symbol |
HD5, NY-CO-9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone deacetylase 5
|
| Other Description |
antigen NY-CO-9
|
| Swissprots |
C9JFV9 Q9UQL6 Q96DY4 O60340 O60528
|
| Accessions |
DAA00017 EAW51633 EAW51634 Q9UQL6 AB011172 BAA25526 AB177853 BAD66831 AF039691 AAC18040 AF132608 AAD29047 AK027734 BAB55329 AK075095 AK093150 AK294760 BAG57895 BC011260 BC013140 AAH13140 BC038423 BC041914 BC051824 AAH51824 BM564861 BM998071 CN290533 XM_005256904 XP_005256961 XM_005256905 XP_005256962 XM_005256906 XP_005256963 XM_005256907 XP_005256964 XM_011524149 XP_011522451 XM_011524150 XP_011522452 XM_011524151 XP_011522453 XR_934338 NM_001015053 NP_001015053 NM_005474 NP_005465 NM_139205
|
| Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:24413532}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Viral carcinogenesis, Epstein-Barr virus infection, Alcoholism
|