HDAC5

Gene Symbol HDAC5
Entrez Gene 10014
Alt Symbol HD5, NY-CO-9
Species Human
Gene Type protein-coding
Description histone deacetylase 5
Other Description antigen NY-CO-9
Swissprots C9JFV9 Q9UQL6 Q96DY4 O60340 O60528
Accessions DAA00017 EAW51633 EAW51634 Q9UQL6 AB011172 BAA25526 AB177853 BAD66831 AF039691 AAC18040 AF132608 AAD29047 AK027734 BAB55329 AK075095 AK093150 AK294760 BAG57895 BC011260 BC013140 AAH13140 BC038423 BC041914 BC051824 AAH51824 BM564861 BM998071 CN290533 XM_005256904 XP_005256961 XM_005256905 XP_005256962 XM_005256906 XP_005256963 XM_005256907 XP_005256964 XM_011524149 XP_011522451 XM_011524150 XP_011522452 XM_011524151 XP_011522453 XR_934338 NM_001015053 NP_001015053 NM_005474 NP_005465 NM_139205
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:24413532}.
Subcellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
Tissue Specificity Ubiquitous.
Top Pathways Viral carcinogenesis, Epstein-Barr virus infection, Alcoholism

Active human HDAC5 full length protein - ab80348 from Abcam

Category Protein
Prices $488.00
Sizes 5 µg
Source Baculovirus infected sf9 cells
Species Human
Image showing specific activity of ab80348.

Active human HDAC5 protein fragment - ab80351 from Abcam

Category Protein
Prices $466.00
Sizes 5 µg
Source Baculovirus infected sf9 cells
Species Human

Human HDAC5 peptide - ab41707 from Abcam

Category Peptide
Species Human

Recombinant Human HDAC5 Protein - H00010014-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

HDAC 5 Blocking Peptide - 33R-10520 from Fitzgerald

Category Peptide
Prices $295.00
Sizes 50 µg

HDAC5 Blocking Peptide - 33R-10830 from Fitzgerald

Category Peptide
Prices $145.00
Sizes 50 µg

Histone Deacetylase 5 (phospho-Ser498) Blocking Peptide - abx063638 from Abbexa

Category Peptide
Species Human, Mouse, Rat, Bovine, Pig

Histone Deacetylase 5 Blocking Peptide - abx063639 from Abbexa

Category Peptide
Species Human, Mouse, Rat, Bovine, Dog, Pig

Histone Deacetylase 5 Blocking Peptide - abx063640 from Abbexa

Category Peptide
Species Human, Mouse, Rat, Bovine, Pig

HDAC5 - H00010014-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

HDAC5 - H00010014-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

HDAC5 control peptide - AP00274CP-N from Acris Antibodies

Category Peptide
Prices $205.00
Sizes 50 µg

Recombinant HDAC5 protein, catalytic domain - 31351 from ActiveMotif

Category Protein
Prices $395.00
Sizes 10 µg
Source Baculovirus
Species Human
HDAC5 catalytic domain activity assay. Recombinant HDAC5 catalytic domain activity measured using a fluorescent HDAC assay.

HDAC-5, Active Human Recombinant Protein - GWB-C87EF0 from Genway Biotech

Category Protein
Prices $600.00
Sizes 10 µg
Species Human
HDAC-5, Active Human Recombinant Protein

HDAC-5 full length, Active Human Recombinant Protein - GWB-74FD17 from Genway Biotech

Category Protein
Prices $612.00
Sizes 5 µg
Species Human
HDAC-5 full length, Active Human Recombinant Protein

HDAC5 (Phospho-Ser498) Antibody Blocking Peptide - GWB-4C7135 from Genway Biotech

Category Peptide
Prices $138.00
Sizes 100 µg

Recombinant Human Histone Deacetylase 5, GST-tagged - HDAC5-396H from Creative Biomart

Category Protein
Source HDAC5 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.

Recombinant Human HDAC5, GST-tagged - HDAC5-28267TH from Creative Biomart

Category Protein

Recombinant Human HDAC5, His-tagged - HDAC5-28921TH from Creative Biomart

Category Protein

Recombinant Histone Deacetylase 5 (HDAC5) - RPE905Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

HDAC5, His, Human - Z03083-50 from GenScript

Category Protein
Prices $175.00
Sizes 50 μg
Source Sf9 insect cells
Species Human

HDAC5, His, Human - Z03083-10 from GenScript

Category Protein
Prices $49.00
Sizes 10 μg
Source Sf9 insect cells
Species Human

Histone Deacetylase 5 (pS498) Blocking Peptide - CBP2444 from Cohesion Biosciences

Category Peptide
Prices $150.00, $450.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat, Bovine, Pig

Histone Deacetylase 5 Blocking Peptide - CBP2445 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat, Bovine, Dog, Pig

Histone Deacetylase 5 Blocking Peptide - CBP2446 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat, Bovine, Pig
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