DDHD2

Gene Symbol DDHD2
Entrez Gene 23259
Alt Symbol SAMWD1, SPG54, iPLA(1)gamma
Species Human
Gene Type protein-coding
Description DDHD domain containing 2
Other Description PA-PLA1 like|SAM, WWE and DDHD domain-containing protein 1|intracellular phospholipase A1gamma|phospholipase DDHD2|sec23p-interacting protein p125-like phosphatidic acid-preferring phospholipase A1
Swissprots B3KXB5 O94830 Q9H8X7 B3KWV2
Accessions EAW63323 EAW63324 O94830 AB018268 BAA34445 AK023218 BAB14470 AK026961 AK056525 BAG51738 AK094951 AK125904 BAG54264 AK127040 BAG54427 AK299875 BAG61725 BC010504 AAH10504 BI789108 BM510691 DA333302 DA412370 XM_005273454 XP_005273511 XM_005273455 XP_005273512 XM_005273456 XP_005273513 XM_005273457 XP_005273514 XM_011544455 XP_011542757 XM_011544456 XP_011542758 XR_247123 XR_949383 XR_949384 XR_949385 XR_949386 XR_949387 NM_001164232 NP_001157704 NM_001164234 NP_001157706 NM_015214 NP_056029
Function Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. {ECO:0000269|PubMed:11788596, ECO:0000269|PubMed:20932832, ECO:0000269|PubMed:22922100}.
Subcellular Location Cytoplasm, cytosol. Endoplasmic reticulum- Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P.
Tissue Specificity Widely expressed (at protein level). {ECO:0000269|PubMed:11788596}.

DDHD2 293T Cell Transient Overexpression Lysate(Denatured) - H00023259-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

DDHD2 Overexpression Lysate (Native) - NBP2-10159 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: DDHD2 Overexpression Lysate (Adult Normal) [NBP2-10159] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DDHD2.

DDHD2 Overexpression Lysate (Denatured) - H00023259-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human DDHD2 Knockdown Stable Cell Line - CSC-DC004120 from Creative biogene

Category Cell Line
Species Human
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