TSG101

Gene Symbol	TSG101
Entrez Gene	7251
Alt Symbol	TSG10, VPS23
Species	Human
Gene Type	protein-coding
Description	tumor susceptibility 101
Other Description	ESCRT-I complex subunit TSG101|tumor susceptibility gene 10|tumor susceptibility gene 101|tumor susceptibility gene 101 protein|tumor susceptibility protein
Swissprots	Q9BUM5 Q99816
Accessions	EAW68381 EAW68382 EAW68383 EAW68384 EAW68385 EAW68386 Q99816 AK130787 AU138453 AY207473 AAO59169 AY207474 AAO59170 BC002487 AAH02487 BP347883 CB528488 DQ892792 ABM83718 DQ896039 ABM87038 U82130 AAC52083 XM_005253108 XP_005253165 NM_006292 NP_006283
Function	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351}.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TSG101 protein fragment - ab92261 from Abcam Category Protein Source E. coli Species Human

TSG101 peptide - ab30870 from Abcam Category Peptide

TSG101 Antibody Blocking Peptide - LS-E11821 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TSG101 Antibody Blocking Peptide - LS-E13375 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TSG101 Antibody Blocking Peptide - LS-E6903 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TSG101 Antibody Blocking Peptide - LS-E6904 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TSG101 Partial Recombinant Protein - H00007251-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TSG101 Partial Recombinant Protein - H00007251-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Recombinant Human TSG101 Protein - H00007251-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human TSG101 Protein - NBP1-44489 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E. coli Species Human

TSG101 Peptide - P0962 from Novus Biologicals Category Peptide Species Human

TSG101 Peptide - P0961 from Novus Biologicals Category Peptide Species Human

TSG101-Antibody-C-term-Blocking-Peptide - BP2155b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TSG101-Antibody-N-term-Blocking-Peptide - BP2155a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TSG101 Protein (OPPA02387) - OPPA02387 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. coli

Human Tumor Susceptibility Gene 101 protein - orb81443 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

TSG101 Blocking Peptide - 33R-10190 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TSG101 Blocking Peptide - 33R-8177 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TSG101 protein (His tag) - 80R-1296 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

TSG101 (1-145, His-tag) - AR09431PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

TSG101 (1-145, His-tag) - AR09431PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

TSG101 - H00007251-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

TSG101 - H00007251-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TSG101 - H00007251-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TSG101 - H00007251-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

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