TSG101

Gene Symbol	TSG101
Entrez Gene	7251
Alt Symbol	TSG10, VPS23
Species	Human
Gene Type	protein-coding
Description	tumor susceptibility 101
Other Description	ESCRT-I complex subunit TSG101\|tumor susceptibility gene 10\|tumor susceptibility gene 101\|tumor susceptibility gene 101 protein\|tumor susceptibility protein
Swissprots	Q9BUM5 Q99816
Accessions	EAW68381 EAW68382 EAW68383 EAW68384 EAW68385 EAW68386 Q99816 AK130787 AU138453 AY207473 AAO59169 AY207474 AAO59170 BC002487 AAH02487 BP347883 CB528488 DQ892792 ABM83718 DQ896039 ABM87038 U82130 AAC52083 XM_005253108 XP_005253165 NM_006292 NP_006283
Function	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. {ECO:0000269\|PubMed:11916981, ECO:0000269\|PubMed:17556548, ECO:0000269\|PubMed:17853893, ECO:0000269\|PubMed:21070952, ECO:0000269\|PubMed:21757351}.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
Top Pathways	Endocytosis

tsg 101 (C-2) - sc-7964 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

tsg 101 (C-2): sc-7964. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tumor showing cytoplasmic localization.

tsg 101 (M-19) - sc-6037 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

tsg 101 (M-19): sc-6037. Western blot analysis of tsg 101 expression in Hs68 (A), 3611-RF (B), NIH/3T3 (C), C3H/10T1/2 (D) and MDCK (E) whole cell lysates.

tsg 101 (H-270) - sc-22774 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

tsg 101 (51) - sc-136111 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Mouse
Clonality	Monoclonal

tsg 101 (51): sc-136111. Western blot analysis of tsg 101 expression in K-562 whole cell lysate.

tsg 101 (Y16J) - sc-101254 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

tsg 101 (Y16J): sc-101254. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing nuclear localization.

Anti-TSG101 antibody - ab30871 from Abcam

Prices	$390.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-TSG101 antibody (ab30871) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 3 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 4 : HEK293 Human embryonic kidney cell line Whole Cell Lysate Lane 5 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lane 6 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell Lysate Lane 7 : SHSY-5Y (Human neuroblastoma cell line) Whole Cell Lysate Lane 8 : U2OS (Human osteosarcoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-TSG101 antibody - ab76326 from Abcam

Host	Rabbit
Clonality	Polyclonal

Anti-TSG101 antibody - ab70120 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-TSG101 antibody (ab70120) at 1/500 dilutionLane 1 : COS7 cell extractsLane 2 : COS7 cell extracts with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-TSG101 antibody - ab70974 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TSG101 antibody (ab70974) at 1/100 dilution + ZR75-1 cell lysate at 12.5 µg

Anti-TSG101 antibody [4A10] - ab83 from Abcam

Prices	$401.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	4A10

All lanes : Anti-TSG101 antibody [4A10] (ab83)Lane 1 : 20ug HeLa cell extractLane 2 : 20ug HeLa cell extract from cells treated with TSG101 siRNA

Anti-TSG101 antibody [5B7] - ab117627 from Abcam

Prices	$384.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	5B7

ELISA showing the detection limit for recombinant proprietary tagged TSG101 is approximately 0.03 ng/ml as a capture antibody (ab117627).

Anti-TSG101 antibody [EPR7130(B)] - ab125011 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR7130(B)

All lanes : Anti-TSG101 antibody [EPR7130(B)] (ab125011) at 1/1000 dilution (unpurified)Lane 1 : Jurkat cell lysateLane 2 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-TSG101 antibody [EPR7131(B)] - ab133586 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR7131(B)

All lanes : Anti-TSG101 antibody [EPR7131(B)] (ab133586) at 1/1000 dilutionLane 1 : PC12 cell lysate Lane 2 : NIH 3T3 cell lysate Lane 3 : 293T cell lysate Lane 4 : Jurkat cell lysate Lysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti-Rabbit IgG at 1/2000 dilution

Anti-TSG101 Antibody (aa167-374, clone 4A10) - LS-C20061 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	4A10

Anti-TSG101 Antibody (aa167-374, clone 4H9) - LS-C53398 from LifeSpan Bioscience

Prices	$445.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	4H9

Anti-TSG101 Antibody (aa167-374, clone 1E5) - LS-C83568 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1E5

Anti-TSG101 Antibody (aa280-330) - LS-C95199 from LifeSpan Bioscience

Prices	$325.00
Sizes	500 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TSG101 Antibody (C-Terminus) - LS-C30930 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TSG101 Antibody (aa164-213) - LS-C30934 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TSG101 Antibody (N-Terminus, AP) - LS-C220951 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TSG101 Antibody (N-Terminus, APC) - LS-C220952 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TSG101 Antibody (N-Terminus, Biotin) - LS-C220953 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TSG101 Antibody (N-Terminus, FITC) - LS-C220955 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TSG101 Antibody (N-Terminus) - LS-C187133 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

TSG101 antibody Western Blot of Thymus tumor. Antibody dilution: 1 ug/ml.

Anti-TSG101 Antibody (N-Terminus, Azide-free, HRP) - LS-C220956 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

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