TSG101

Gene Symbol	TSG101
Entrez Gene	7251
Alt Symbol	TSG10, VPS23
Species	Human
Gene Type	protein-coding
Description	tumor susceptibility 101
Other Description	ESCRT-I complex subunit TSG101|tumor susceptibility gene 10|tumor susceptibility gene 101|tumor susceptibility gene 101 protein|tumor susceptibility protein
Swissprots	Q9BUM5 Q99816
Accessions	EAW68381 EAW68382 EAW68383 EAW68384 EAW68385 EAW68386 Q99816 AK130787 AU138453 AY207473 AAO59169 AY207474 AAO59170 BC002487 AAH02487 BP347883 CB528488 DQ892792 ABM83718 DQ896039 ABM87038 U82130 AAC52083 XM_005253108 XP_005253165 NM_006292 NP_006283
Function	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351}.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

tsg 101 CRISPR/Cas9 KO Plasmid (h) - sc-400290 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

tsg 101 HDR Plasmid (h) - sc-400290-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

tsg 101 Double Nickase Plasmid (h) - sc-400290-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

tsg 101 Double Nickase Plasmid (h2) - sc-400290-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

tsg 101 CRISPR Activation Plasmid (h) - sc-400290-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

tsg 101 CRISPR Activation Plasmid (h2) - sc-400290-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

tsg 101 Lentiviral Activation Particles (h) - sc-400290-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

tsg 101 Lentiviral Activation Particles (h2) - sc-400290-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

tsg 101 siRNA (h) - sc-36752 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

tsg 101 shRNA Plasmid (h) - sc-36752-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

tsg 101 shRNA (h) Lentiviral Particles - sc-36752-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TSG101 RNAi - H00007251-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TSG101 RNAi - H00007251-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU124061 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22084 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22084 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

TSG101 siRNA (Human) - CRH4955 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TSG101 - MBS8219456 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TSG101 (NM_006292.3) - SHH436020 from Creative biogene Category siRNA Species Reactivities Human

TSG101 shRNA Plasmid (Human) - CHH4955 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TSG101 miRNA 3'UTR clone - MiUTR3H-04089 from Creative biogene Species Reactivities Human

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