PAK2

Gene Symbol PAK2
Entrez Gene 5062
Alt Symbol PAK65, PAKgamma
Species Human
Gene Type protein-coding
Description p21 protein (Cdc42/Rac)-activated kinase 2
Other Description PAK-2|S6/H4 kinase|gamma-PAK|p21 (CDKN1A)-activated kinase 2|p21-activated kinase 2|p58|serine/threonine-protein kinase PAK 2
Swissprots Q6ISC3 Q13177 Q13154
Accessions AFG72980 Q13177 AI140979 AK291339 BAF84028 BC031667 BC046197 BC063539 BC069613 AAH69613 BG572555 CA445078 DB164364 DQ786200 U24153 AAA65442 U25975 AAA75468 XM_011512870 XP_011511172 NM_002577 NP_002568
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF- induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the o
Subcellular Location Serine/threonine-protein kinase PAK 2: Cytoplasm. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.
Tissue Specificity Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.
Top Pathways Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, MAPK signaling pathway

HTScan® PAK2 Kinase Assay Kit - 7636 from Cell Signaling Technology

Category Assay Kit
Figure 1. PAK2 kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 3 mM MgCl2, 3 mM MnCl2, 3 µM Na-orthovanadate, 1.2 mM DTT, ATP (variable), 2.5 µg/50 µl PEG20.000, Substrate: Tetra (LRRWSLG), 5 µg/50 µl, recombinant PAK1: 50 ng/50 µl.

Mouse/Human/Rat Phospho-PAK2 (Ser20) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1269 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-PAK2 (Ser141) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1694 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-PAK2 (Ser192) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1693 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat PAK2 ELISA Kit (Cell-Based ELISA) - LS-F2221 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Serine/threonine-protein kinase PAK 2 (PAK2), Human, ELISA Kit - CSB-EL017406HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

PAK2 Colorimetric Cell-Based ELISA Kit - CB5530 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

PAK2 (Phospho-Ser20) Colorimetric Cell-Based ELISA Kit - CBP1269 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

PAK2 (Phospho-Ser192) Colorimetric Cell-Based ELISA Kit - CBP1762 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

PAK2 (Phospho-Ser141) Colorimetric Cell-Based ELISA Kit - CBP1763 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

p21 protein (Cdc42/Rac) -activated kinase 2, ELISA Kit - MBS910526 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Serine/threonine-protein kinase PAK 2(PAK2) ELISA kit - CSB-EL017406HU from Cusabio

Category ELISA Kit
Sensitivity 4.69 pg/ml
Range Request Information

Human Phospho-PAK2 (Ser20) ELISA - PEL-PAK2-S20-1 from RayBiotech

Category ELISA Kit
Prices $481.00, $865.80, $1,924.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Phospho-PAK2 (Ser20) and Total PAK2 ELISA - PEL-PAK2-S20-T-1 from RayBiotech

Category ELISA Kit
Prices $525.00, $945.00, $2,100.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit
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