PAK2

Gene Symbol	PAK2
Entrez Gene	5062
Alt Symbol	PAK65, PAKgamma
Species	Human
Gene Type	protein-coding
Description	p21 protein (Cdc42/Rac)-activated kinase 2
Other Description	PAK-2|S6/H4 kinase|gamma-PAK|p21 (CDKN1A)-activated kinase 2|p21-activated kinase 2|p58|serine/threonine-protein kinase PAK 2
Swissprots	Q6ISC3 Q13177 Q13154
Accessions	AFG72980 Q13177 AI140979 AK291339 BAF84028 BC031667 BC046197 BC063539 BC069613 AAH69613 BG572555 CA445078 DB164364 DQ786200 U24153 AAA65442 U25975 AAA75468 XM_011512870 XP_011511172 NM_002577 NP_002568
Function	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF- induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the o
Subcellular Location	Serine/threonine-protein kinase PAK 2: Cytoplasm. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.
Tissue Specificity	Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.
Top Pathways	Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® PAK2 siRNA II - 6507 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® PAK2 siRNA I - 6467 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence® PAK2 siRNA (Human Specific) - 6366 from Cell Signaling Technology Category siRNA

γPAK CRISPR/Cas9 KO Plasmid (h) - sc-401595 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

γPAK HDR Plasmid (h) - sc-401595-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

γPAK Double Nickase Plasmid (h) - sc-401595-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

γPAK Double Nickase Plasmid (h2) - sc-401595-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

γPAK CRISPR Activation Plasmid (h) - sc-401595-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

γPAK CRISPR Activation Plasmid (h2) - sc-401595-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

γPAK Lentiviral Activation Particles (h) - sc-401595-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

γPAK Lentiviral Activation Particles (h2) - sc-401595-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

γPAK siRNA (h) - sc-36183 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

γPAK shRNA Plasmid (h) - sc-36183-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

γPAK shRNA (h) Lentiviral Particles - sc-36183-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU026721 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1488 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1487 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1486 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN16287 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16287 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

PAK2 siRNA (Human) - CRH3363 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PAK2 RNAi - H00005062-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human PAK2 (NM_002577.4) - SHH370160 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PAK2(NM_002577.4) - SHR086010 from Creative biogene Category siRNA Species Reactivities Human

Human PAK2 siRNA - orb263865 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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