| Gene Symbol | PAK2 |
|---|---|
| Entrez Gene | 5062 |
| Alt Symbol | PAK65, PAKgamma |
| Species | Human |
| Gene Type | protein-coding |
| Description | p21 protein (Cdc42/Rac)-activated kinase 2 |
| Other Description | PAK-2|S6/H4 kinase|gamma-PAK|p21 (CDKN1A)-activated kinase 2|p21-activated kinase 2|p58|serine/threonine-protein kinase PAK 2 |
| Swissprots | Q6ISC3 Q13177 Q13154 |
| Accessions | AFG72980 Q13177 AI140979 AK291339 BAF84028 BC031667 BC046197 BC063539 BC069613 AAH69613 BG572555 CA445078 DB164364 DQ786200 U24153 AAA65442 U25975 AAA75468 XM_011512870 XP_011511172 NM_002577 NP_002568 |
| Function | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF- induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the o |
| Subcellular Location | Serine/threonine-protein kinase PAK 2: Cytoplasm. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane. |
| Tissue Specificity | Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen. |
| Top Pathways | Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, MAPK signaling pathway |