| Gene Symbol |
PDCL3
|
| Entrez Gene |
79031
|
| Alt Symbol |
HTPHLP, PHLP2A, PHLP3, VIAF, VIAF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosducin-like 3
|
| Other Description |
IAP-associated factor VIAF1|VIAF-1|phPL3|phosducin-like protein 3|viral IAP-associated factor 1
|
| Swissprots |
Q9H2J4 B2RA00 Q53S68
|
| Accessions |
AAX93227 EAX01837 EAX01838 Q9H2J4 AF110511 AAG21887 AF267853 AAG44722 AI741007 AK300827 BAH13356 AK313985 BAG36697 BC001021 AAH01021 BG819099 BI820064 HQ448695 ADQ33173 NM_024065 NP_076970
|
| Function |
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination. {ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:23792958}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15371430}.
|
| Tissue Specificity |
Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon. {ECO:0000269|PubMed:15371430}.
|