Gene Symbol | PDCL3 |
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Entrez Gene | 79031 |
Alt Symbol | HTPHLP, PHLP2A, PHLP3, VIAF, VIAF1 |
Species | Human |
Gene Type | protein-coding |
Description | phosducin-like 3 |
Other Description | IAP-associated factor VIAF1|VIAF-1|phPL3|phosducin-like protein 3|viral IAP-associated factor 1 |
Swissprots | Q9H2J4 B2RA00 Q53S68 |
Accessions | AAX93227 EAX01837 EAX01838 Q9H2J4 AF110511 AAG21887 AF267853 AAG44722 AI741007 AK300827 BAH13356 AK313985 BAG36697 BC001021 AAH01021 BG819099 BI820064 HQ448695 ADQ33173 NM_024065 NP_076970 |
Function | Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination. {ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:23792958}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15371430}. |
Tissue Specificity | Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon. {ECO:0000269|PubMed:15371430}. |
PDCL3 CRISPR/Cas9 KO Plasmid (h) - sc-417884 from Santa Cruz Biotechnology
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PDCL3 HDR Plasmid (h) - sc-417884-HDR from Santa Cruz Biotechnology
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PDCL3 Double Nickase Plasmid (h) - sc-417884-NIC from Santa Cruz Biotechnology
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PDCL3 Double Nickase Plasmid (h2) - sc-417884-NIC-2 from Santa Cruz Biotechnology
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PDCL3 CRISPR Activation Plasmid (h) - sc-417884-ACT from Santa Cruz Biotechnology
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PDCL3 CRISPR Activation Plasmid (h2) - sc-417884-ACT-2 from Santa Cruz Biotechnology
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PDCL3 Lentiviral Activation Particles (h) - sc-417884-LAC from Santa Cruz Biotechnology
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PDCL3 Lentiviral Activation Particles (h2) - sc-417884-LAC-2 from Santa Cruz Biotechnology
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PDCL3 siRNA (h) - sc-94814 from Santa Cruz Biotechnology
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PDCL3 shRNA Plasmid (h) - sc-94814-SH from Santa Cruz Biotechnology
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PDCL3 shRNA (h) Lentiviral Particles - sc-94814-V from Santa Cruz Biotechnology
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PDCL3 RNAi - H00079031-R01 from Novus Biologicals
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MISSION® esiRNA - EHU110031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16526 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16526 from Sigma-Aldrich
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PDCL3 siRNA (Human) - CRJ2267 from Cohesion Biosciences
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shRNA set against Human PDCL3 (NM_024065.4) - SHH372296 from Creative biogene
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shRNA set against Human PDCL3(NM_024065.4) - SHR099224 from Creative biogene
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PDCL3 shRNA Plasmid (Human) - CHJ2267 from Cohesion Biosciences
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PDCL3 miRNA 3'UTR clone - MiUTR1H-07699 from Creative biogene
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