| Gene Symbol |
SERPINA3
|
| Entrez Gene |
12
|
| Alt Symbol |
AACT, ACT, GIG24, GIG25
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
|
| Other Description |
alpha-1-antichymotrypsin|cell growth-inhibiting gene 24/25 protein|growth-inhibiting protein 24|growth-inhibiting protein 25|serine (or cysteine) proteinase inhibitor, clade A, member 3|serpin A3
|
| Swissprots |
Q6LBY8 P01011 Q9UC47 Q6LDT7 Q59GP9 Q9UNU9 B3KVQ7 Q6NSC9 Q13703 Q96DW8 Q8N177 Q2TU88 Q2TU87
|
| Accessions |
CAA25459 CAA48671 CAI95958 EAW81587 EAW81588 EAW81589 EAW81590 P01011 AB209060 BAD92297 AF089747 AAD08810 AK093049 BAG52641 AK096120 AK123091 BAG53869 AK308565 AY513275 AAT08028 AY513276 AAT08029 BC003559 AAH03559 BC010530 AAH10530 BC013189 AAH13189 BC034554 AAH34554 BC070265 AAH70265 BG565041 CB111903 HQ448280 ADQ32760 J05176 AAA51560 K01500 AAA51543 M18906 AAA51559 M22533 NM_001085 NP_001076
|
| Function |
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. {ECO:0000269|PubMed:2404007}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. {ECO:0000269|PubMed:3257719, ECO:0000269|PubMed:9880565}.
|
![Western Blot: Serpin A3/alpha 1-Antichymotrypsin Overexpression Lysate (Denatured) [H00000012-T01] - Lane 1: SERPINA3 transfected lysate (47.7 KDa) Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/81_Serpin-A3-alpha-1-Antichymotrypsin-Overexpression-Lysate-(Denatured)-Western-Blot-H00000012-T01-img0004.jpg)