SERPINA3

Gene Symbol SERPINA3
Entrez Gene 12
Alt Symbol AACT, ACT, GIG24, GIG25
Species Human
Gene Type protein-coding
Description serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Other Description alpha-1-antichymotrypsin|cell growth-inhibiting gene 24/25 protein|growth-inhibiting protein 24|growth-inhibiting protein 25|serine (or cysteine) proteinase inhibitor, clade A, member 3|serpin A3
Swissprots Q6LBY8 P01011 Q9UC47 Q6LDT7 Q59GP9 Q9UNU9 B3KVQ7 Q6NSC9 Q13703 Q96DW8 Q8N177 Q2TU88 Q2TU87
Accessions CAA25459 CAA48671 CAI95958 EAW81587 EAW81588 EAW81589 EAW81590 P01011 AB209060 BAD92297 AF089747 AAD08810 AK093049 BAG52641 AK096120 AK123091 BAG53869 AK308565 AY513275 AAT08028 AY513276 AAT08029 BC003559 AAH03559 BC010530 AAH10530 BC013189 AAH13189 BC034554 AAH34554 BC070265 AAH70265 BG565041 CB111903 HQ448280 ADQ32760 J05176 AAA51560 K01500 AAA51543 M18906 AAA51559 M22533 NM_001085 NP_001076
Function Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. {ECO:0000269|PubMed:2404007}.
Subcellular Location Secreted.
Tissue Specificity Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. {ECO:0000269|PubMed:3257719, ECO:0000269|PubMed:9880565}.

AACT CRISPR/Cas9 KO Plasmid (h) - sc-405262 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AACT HDR Plasmid (h) - sc-405262-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AACT Double Nickase Plasmid (h) - sc-405262-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AACT Double Nickase Plasmid (h2) - sc-405262-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AACT CRISPR Activation Plasmid (h) - sc-405262-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AACT CRISPR Activation Plasmid (h2) - sc-405262-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AACT Lentiviral Activation Particles (h) - sc-405262-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AACT Lentiviral Activation Particles (h2) - sc-405262-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AACT siRNA (h) - sc-40944 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AACT shRNA Plasmid (h) - sc-40944-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AACT shRNA (h) Lentiviral Particles - sc-40944-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU150301 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1900 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1900 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01181 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01181

SERPINA3 siRNA (Human) - CRH0005 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Serpin A3/alpha 1-Antichymotrypsin RNAi - H00000012-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SERPINA3 - MBS8231588 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SERPINA3(NM_001085.4) - SHR216672 from Creative biogene

Category siRNA
Species Reactivities Human

Human SERPINA3 siRNA - orb260507 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SERPINA3 shRNA Plasmid (Human) - CHH0005 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SERPINA3 miRNA 3'UTR clone - MiUTR1H-09294 from Creative biogene

Species Reactivities Human
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