RAB5A

Gene Symbol	RAB5A
Entrez Gene	5868
Alt Symbol	RAB5
Species	Human
Gene Type	protein-coding
Description	RAB5A, member RAS oncogene family
Other Description	RAS-associated protein RAB5A|ras-related protein Rab-5A
Swissprots	Q6FI44 P20339 B4DJA5
Accessions	EAW64301 EAW64302 EAW64303 P20339 AF464088 AAO15677 AF498936 AAM21084 AK295992 BAG58767 AK309287 AK312618 BAG35504 AM392797 CAL37675 AM393001 CAL37879 BC001267 AAH01267 BC018288 AAH18288 BJ991078 CR536492 CAG38731 DA972638 DC330362 DQ891790 ABM82716 DQ894972 ABM85898 M28215 AAA60245 X13903 CAA32103 NM_001292048 NP_001278977 NM_004162 NP_004153
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. {ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077}.
Subcellular Location	Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Melanosome. Cytoplasmic vesicle {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Membrane. Cytoplasm, cytosol. Note=Enriched in stage I melanosomes. Alternates between membrane-bound and cytosolic forms.
Top Pathways	Amyotrophic lateral sclerosis (ALS), Endocytosis, Vasopressin-regulated water reabsorption, Phagosome, Amoebiasis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-RAB5A-cDNA-Clone - DC00589 from Abgent, a WuXi AppTec company Prices $290.25 Sizes 10 µg Species Human Accession BC001267

RAB5A - MBS1274955 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC001267

Human RAB5A Gene ORF cDNA clone in cloning vector - HG14013-G from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14013-CF from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, C-His tag - HG14013-CH from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14013-CM from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, N-HA tag - HG14013-NY from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14013-ACR from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid - HG14013-UT from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, C-HA tag - HG14013-CY from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14013-ACG from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, N-His tag - HG14013-NH from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14013-NF from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14013-NM from Sino Biological Species Human

Human RAB5A ORF Clone (BC001267) - CDCS411645 from Creative biogene Species Human Accession P20339

Human RAB5A ORF clone (BC001267) - CDCB159471 from Creative biogene Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14013-ANR from Sino Biological Species Human

Human RAB5A Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14013-ANG from Sino Biological Species Human

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