RAB5A

Gene Symbol	RAB5A
Entrez Gene	5868
Alt Symbol	RAB5
Species	Human
Gene Type	protein-coding
Description	RAB5A, member RAS oncogene family
Other Description	RAS-associated protein RAB5A|ras-related protein Rab-5A
Swissprots	Q6FI44 P20339 B4DJA5
Accessions	EAW64301 EAW64302 EAW64303 P20339 AF464088 AAO15677 AF498936 AAM21084 AK295992 BAG58767 AK309287 AK312618 BAG35504 AM392797 CAL37675 AM393001 CAL37879 BC001267 AAH01267 BC018288 AAH18288 BJ991078 CR536492 CAG38731 DA972638 DC330362 DQ891790 ABM82716 DQ894972 ABM85898 M28215 AAA60245 X13903 CAA32103 NM_001292048 NP_001278977 NM_004162 NP_004153
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. {ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077}.
Subcellular Location	Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Melanosome. Cytoplasmic vesicle {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Membrane. Cytoplasm, cytosol. Note=Enriched in stage I melanosomes. Alternates between membrane-bound and cytosolic forms.
Top Pathways	Amyotrophic lateral sclerosis (ALS), Endocytosis, Vasopressin-regulated water reabsorption, Phagosome, Amoebiasis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active rat Rab5 full length protein - ab90108 from Abcam Category Protein Prices $239.00 Sizes 50 µg Source E. coli Species Rat

D. melanogaster Rab5 peptide - ab32489 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Drosophila

Human Rab5 (mutated Q79 L) protein fragment - ab176622 from Abcam Category Protein Source E. coli Species Human

Human Rab5 full length protein - ab62956 from Abcam Category Protein Source E. coli Species Human

Human Rab5 peptide - ab18625 from Abcam Category Peptide

Human Rab5 protein fragment - ab176618 from Abcam Category Protein Source E. coli Species Human

RAB5A / RAB5 Antibody Blocking Peptide - LS-E20556 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB5A / RAB5 Antibody Blocking Peptide - LS-E20555 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB5A / RAB5 Antibody Blocking Peptide - LS-E22370 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB5A / RAB5 Antibody Blocking Peptide - LS-E22371 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB5A / RAB5 Antibody Blocking Peptide - LS-E8577 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Rab5a Recombinant Protein - H00005868-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Rab5a Partial Recombinant Protein - H00005868-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Rab5a Protein - NBC1-18504 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Species Human

Rab5-Antibody-C-term-Blocking-Peptide - BP6974b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RAB5A Protein - GTX108605-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

RAB5A Protein (OPPA01580) - OPPA01580 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human RAB5A protein - orb81294 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human RAB5A protein - orb244483 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

RAB5 Blocking Peptide - 33R-10778 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

RAB5A Blocking Peptide - 33R-8417 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAB5A Blocking Peptide - 33R-4691 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAB5A protein - 30R-1120 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

RAB5A / RAB5 (1-215) - AR09078PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

RAB5A / RAB5 (1-215) - AR09078PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

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