IL1RN
| Gene Symbol | IL1RN |
|---|---|
| Entrez Gene | 3557 |
| Alt Symbol | DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 1 receptor antagonist |
| Other Description | IL1 inhibitor|IL1RN (IL1F3)|interleukin-1 receptor antagonist protein|intracellular IL-1 receptor antagonist type II|intracellular interleukin-1 receptor antagonist (icIL-1ra)|type II interleukin-1 receptor antagonist |
| Swissprots | Q53SC2 Q14628 P18510 Q9UPC0 Q96GD6 Q7RTZ4 A8K4G1 |
| Accessions | AAB41943 AAB92268 AAB92269 AAB92270 AAC13499 AAN87150 AAX93278 CAA03191 CAA03210 CAA45832 CAD29879 CAJ91094 CBY45189 EAW73621 EAW73622 EAW73623 EAW73624 EAW73625 P18510 AF043143 AAC39672 AJ005835 CAA06730 AK290898 BAF83587 AK290926 BAF83615 BC009745 AAH09745 BC068441 BI766516 DQ892566 ABM83492 DQ895781 ABM86707 M55646 AAA59138 X52015 CAA36262 X53296 CAA37386 X84348 CAA59087 XM_005263661 XP_005263718 XM_006712497 XP_006712560 XM_011511121 XP_011509423 NM_000577 NP_000568 NM_173841 NP_776213 NM_173842 NP_776214 NM_173843 NP_776215 |
| Function | Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. {ECO:0000269|PubMed:7775431}. |
| Subcellular Location | Isoform 3: Cytoplasm. |
| Tissue Specificity | The intracellular form of IL1RN is predominantly expressed in epithelial cells. |
IL-1ra CRISPR/Cas9 KO Plasmid (h) - sc-401313 from Santa Cruz Biotechnology
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IL-1ra HDR Plasmid (h) - sc-401313-HDR from Santa Cruz Biotechnology
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IL-1ra Double Nickase Plasmid (h) - sc-401313-NIC from Santa Cruz Biotechnology
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IL-1ra Double Nickase Plasmid (h2) - sc-401313-NIC-2 from Santa Cruz Biotechnology
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IL-1ra CRISPR Activation Plasmid (h) - sc-401313-ACT from Santa Cruz Biotechnology
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IL-1ra CRISPR Activation Plasmid (h2) - sc-401313-ACT-2 from Santa Cruz Biotechnology
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IL-1ra Lentiviral Activation Particles (h) - sc-401313-LAC from Santa Cruz Biotechnology
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IL-1ra Lentiviral Activation Particles (h2) - sc-401313-LAC-2 from Santa Cruz Biotechnology
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IL-1ra siRNA (h) - sc-39617 from Santa Cruz Biotechnology
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IL-1ra shRNA Plasmid (h) - sc-39617-SH from Santa Cruz Biotechnology
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IL-1ra shRNA (h) Lentiviral Particles - sc-39617-V from Santa Cruz Biotechnology
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IL-1ra/IL-1F3/IL1RN RNAi - H00003557-R03 from Novus Biologicals
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IL-1ra/IL-1F3/IL1RN RNAi - H00003557-R02 from Novus Biologicals
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MISSION® esiRNA - EHU126081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1752 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1752 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08293 from Sigma-Aldrich
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IL1RN siRNA (Human) - CRH2375 from Cohesion Biosciences
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IL-1ra/IL-1F3/IL1RN RNAi - H00003557-R01 from Novus Biologicals
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IL-1ra/IL-1F3/IL1RN RNAi - H00003557-R04 from Novus Biologicals
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IL1RN - MBS8218104 from MyBioSource
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IL-1ra CRISPR/Cas9 KO Plasmid (h2) - sc-401313-KO-2 from Santa Cruz Biotechnology
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IL-1ra HDR Plasmid (h2) - sc-401313-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human IL1RN (NM_000577.4) - SHH318629 from Creative biogene
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IL1RN shRNA Plasmid (Human) - CHH2375 from Cohesion Biosciences
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